Department of Life and Environmental Sciences, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy.
Department of Pharmaceutical Science, University of Milan, Via Venezian 21, 20133, Milan, Italy.
J Nanosci Nanotechnol. 2021 May 1;21(5):2917-2921. doi: 10.1166/jnn.2021.19056.
Proniosomal drug delivery system is one of the advancements in nanotechnology. Similarly to traditional dosage forms, chemical and physical compatibility of proniosomes components with the active ingredient(s) is a key step in the preformulation process of such systems. In this work, the compatibility of resveratrol with selected excipients in the development of proniosomal formulation was investigated by thermal and spectroscopic techniques. To evaluate the drug-excipient compatibility, different techniques such as differential scanning calorimetric study, attenuated total reflectance Fourier transform infrared spectroscopy study and powder X-ray diffraction were adopted. The results showed that the excipients used in the formulation were compatible with resveratrol.
前体药物传递系统是纳米技术的一项进展。与传统剂型类似，前体药物系统的制剂前工艺的关键步骤是前体药物成分与活性成分（s）的化学和物理相容性。在这项工作中，通过热和光谱技术研究了白藜芦醇与前体药物制剂开发中所选赋形剂的相容性。为了评估药物-赋形剂的相容性，采用了不同的技术，如差示扫描量热法研究、衰减全反射傅里叶变换红外光谱研究和粉末 X 射线衍射。结果表明，配方中使用的赋形剂与白藜芦醇相容。
