通过分子口述实现无差错的人工合成 DNA。

Error-Free Synthetic DNA by Molecular Dictation.

机构信息

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.

出版信息

Trends Biotechnol. 2021 Sep;39(9):861-865. doi: 10.1016/j.tibtech.2021.02.001. Epub 2021 Feb 27.

DOI:10.1016/j.tibtech.2021.02.001

Abstract

Synthetic DNA is the linchpin of the rapidly accelerating biotechnological era and is perhaps the most promising candidate for long-term digital data storage. Despite huge advances, manufacturing error-free DNA at low cost and high throughput remains challenging. Borrowing from well-established sequencing-by-synthesis technologies, we describe a new solution for DNA error correction.

摘要

合成 DNA 是快速发展的生物技术时代的关键，也许是长期数字数据存储最有前途的候选者。尽管取得了巨大进展，但以低成本和高通量制造无错误的 DNA 仍然具有挑战性。借鉴成熟的合成测序技术，我们描述了一种新的 DNA 纠错解决方案。