Institut Curie, Université PSL, CNRS UMR3348, INSERM U1278, 91400 Orsay, France; Université Paris-Saclay, CNRS UMR3348, INSERM U1278, 91400 Orsay, France; Equipe Labellisée Ligue Nationale Contre le Cancer.
Institut Curie, Université PSL, CNRS UMR3348, INSERM U1278, 91400 Orsay, France; Université Paris-Saclay, CNRS UMR3348, INSERM U1278, 91400 Orsay, France; Equipe Labellisée Ligue Nationale Contre le Cancer.
Trends Biochem Sci. 2021 Jul;46(7):579-594. doi: 10.1016/j.tibs.2021.01.009. Epub 2021 Feb 28.
The 3'-end processing of most pre-messenger RNAs (pre-mRNAs) involves RNA cleavage and polyadenylation and is coupled to transcription termination. In both yeast and human cells, pre-mRNA 3'-end cleavage is globally inhibited by DNA damage. Recently, further links between pre-mRNA 3'-end processing and the control of genome stability have been uncovered, as reviewed here. Upon DNA damage, various genes related to the DNA damage response (DDR) escape 3'-end processing inhibition or are regulated through alternative polyadenylation (APA). Conversely, various pre-mRNA 3'-end processing factors prevent genome instability and are found at sites of DNA damage. Finally, the reciprocal link between pre-mRNA 3'-end processing and genome stability control seems important because it is conserved in evolution and involved in disease development.
大多数前体信使 RNA (pre-mRNAs) 的 3'-末端加工涉及 RNA 切割和多聚腺苷酸化，并与转录终止偶联。在酵母和人类细胞中，前体 mRNA 的 3'-末端切割都受到 DNA 损伤的全局抑制。最近，正如这里所综述的，前体 mRNA 3'-末端加工与基因组稳定性控制之间的进一步联系被揭示出来。在 DNA 损伤后，与 DNA 损伤反应 (DDR) 相关的各种基因逃避 3'-末端加工抑制或通过选择性多聚腺苷酸化 (APA) 进行调节。相反，各种前体 mRNA 3'-末端加工因子防止基因组不稳定性，并在 DNA 损伤部位被发现。最后，前体 mRNA 3'-末端加工和基因组稳定性控制之间的相互联系似乎很重要，因为它在进化中是保守的，并与疾病的发展有关。
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