大肠杆菌不耐热肠毒素：抗毒素检测与血清抗毒素水平的比较
Escherichia coli heat-labile enterotoxin: comparison of antitoxin assays and serum antitoxin levels.
作者信息
Wachsmuth I K, Wells J G, Ryder R W
出版信息
Infect Immun. 1977 Nov;18(2):348-51. doi: 10.1128/iai.18.2.348-351.1977.
Abstract
The mouse adrenal tumor cells (Y-1 strain) and the Chinese hamster ovary cells, two routinely used tissue culture assays for Escherichia coli heat-labile enterotoxin (LT), were used to detect serum antitoxin responses in culture-positive patients from several well-defined sources. There was no correlation between a significant antitoxin response and isolation of LT-producing E. coli in two "domestic" diarrheal outbreaks. Serum samples from a third group of individuals in a rural cholera-endemic area consistently demonstrated significant rises in neutralizing antibody to LT.
摘要
小鼠肾上腺肿瘤细胞（Y - 1株）和中国仓鼠卵巢细胞是两种常用于检测大肠杆菌不耐热肠毒素（LT）的组织培养分析方法，被用于检测来自几个明确来源的培养阳性患者的血清抗毒素反应。在两次“家庭内”腹泻暴发中，显著的抗毒素反应与产LT大肠杆菌的分离之间没有相关性。来自霍乱流行农村地区第三组个体的血清样本始终显示出针对LT的中和抗体显著升高。
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本文引用的文献
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