大肠杆菌不耐热肠毒素：抗毒素检测与血清抗毒素水平的比较
Escherichia coli heat-labile enterotoxin: comparison of antitoxin assays and serum antitoxin levels.
作者信息
Wachsmuth I K, Wells J G, Ryder R W
出版信息
Infect Immun. 1977 Nov;18(2):348-51. doi: 10.1128/iai.18.2.348-351.1977.
Abstract
The mouse adrenal tumor cells (Y-1 strain) and the Chinese hamster ovary cells, two routinely used tissue culture assays for Escherichia coli heat-labile enterotoxin (LT), were used to detect serum antitoxin responses in culture-positive patients from several well-defined sources. There was no correlation between a significant antitoxin response and isolation of LT-producing E. coli in two "domestic" diarrheal outbreaks. Serum samples from a third group of individuals in a rural cholera-endemic area consistently demonstrated significant rises in neutralizing antibody to LT.
摘要
小鼠肾上腺肿瘤细胞（Y - 1株）和中国仓鼠卵巢细胞是两种常用于检测大肠杆菌不耐热肠毒素（LT）的组织培养分析方法，被用于检测来自几个明确来源的培养阳性患者的血清抗毒素反应。在两次“家庭内”腹泻暴发中，显著的抗毒素反应与产LT大肠杆菌的分离之间没有相关性。来自霍乱流行农村地区第三组个体的血清样本始终显示出针对LT的中和抗体显著升高。
相似文献
1
Escherichia coli heat-labile enterotoxin: comparison of antitoxin assays and serum antitoxin levels.大肠杆菌不耐热肠毒素：抗毒素检测与血清抗毒素水平的比较
Infect Immun. 1977 Nov;18(2):348-51. doi: 10.1128/iai.18.2.348-351.1977.
2
Humoral immune response to the heat-labile enterotoxin of Escherichia coli in naturally acquired diarrhea and antitoxin determination by passive immune hemolysis.自然获得性腹泻中针对大肠杆菌不耐热肠毒素的体液免疫反应及通过被动免疫溶血法进行抗毒素测定
Infect Immun. 1977 Jun;16(3):781-8. doi: 10.1128/iai.16.3.781-788.1977.
3
Enzyme-linked immunosorbent assay to measure antibodies to purified heat-labile enterotoxins from human and porcine strains of Escherichia coli and to cholera toxin: application in serodiagnosis and seroepidemiology.酶联免疫吸附测定法，用于检测针对人源和猪源大肠杆菌的纯化不耐热肠毒素以及霍乱毒素的抗体：在血清诊断和血清流行病学中的应用。
J Clin Microbiol. 1985 Feb;21(2):174-9. doi: 10.1128/jcm.21.2.174-179.1985.
4
Local intestinal immune response to Escherichia coli heat-labile (LT) enterotoxin: LT antitoxin levels in healthy, diseased and antigen-fed pigs.对大肠杆菌不耐热（LT）肠毒素的局部肠道免疫反应：健康、患病及喂食抗原猪体内的LT抗毒素水平
Comp Immunol Microbiol Infect Dis. 1984;7(3-4):149-55. doi: 10.1016/0147-9571(84)90020-1.
5
Antibodies to heat-labile Escherichia coli enterotoxin in Apaches in Whiteriver, Arizona.亚利桑那州怀特河阿帕奇人血清中针对不耐热大肠杆菌肠毒素的抗体
Infect Immun. 1975 Dec;12(6):1475-7. doi: 10.1128/iai.12.6.1475-1477.1975.
6
Saliva, breast milk, and serum antibody responses as indirect measures of intestinal immunity after oral cholera vaccination or natural disease.口服霍乱疫苗接种或自然感染疾病后，唾液、母乳和血清抗体反应作为肠道免疫的间接指标。
J Clin Microbiol. 1986 Aug;24(2):203-9. doi: 10.1128/jcm.24.2.203-209.1986.
7
Development of a vaccine against experimental cholera and Escherichia coli diarrheal disease.针对实验性霍乱和大肠杆菌腹泻病的疫苗研发。
Infect Immun. 1981 May;32(2):534-41. doi: 10.1128/iai.32.2.534-541.1981.
8
Immunity to enterotoxigenic Escherichia coli.对产肠毒素大肠杆菌的免疫
Infect Immun. 1979 Mar;23(3):729-36. doi: 10.1128/iai.23.3.729-736.1979.
9
Antitoxin responses to infections with enterotoxigenic Escherichia coli.针对产肠毒素大肠杆菌感染的抗毒素反应。
J Infect Dis. 1974 Mar;129(3):330-5. doi: 10.1093/infdis/129.3.330.
10
Diarrhea due to Escherichia coli in the rabbit: a novel mechanism.
J Infect Dis. 1977 Mar;135(3):454-62. doi: 10.1093/infdis/135.3.454.
引用本文的文献
1
Enterotoxigenic Escherichia coli elicits immune responses to multiple surface proteins.肠产毒性大肠杆菌引发针对多种表面蛋白的免疫应答。
Infect Immun. 2010 Jul;78(7):3027-35. doi: 10.1128/IAI.00264-10. Epub 2010 May 10.
2
Enzyme-linked immunosorbent assay to measure antibodies to purified heat-labile enterotoxins from human and porcine strains of Escherichia coli and to cholera toxin: application in serodiagnosis and seroepidemiology.酶联免疫吸附测定法，用于检测针对人源和猪源大肠杆菌的纯化不耐热肠毒素以及霍乱毒素的抗体：在血清诊断和血清流行病学中的应用。
J Clin Microbiol. 1985 Feb;21(2):174-9. doi: 10.1128/jcm.21.2.174-179.1985.
3
Protective effect of active immunization with purified Escherichia coli heat-labile enterotoxin in rats.纯化大肠杆菌不耐热肠毒素主动免疫对大鼠的保护作用。
Infect Immun. 1979 Mar;23(3):592-9. doi: 10.1128/iai.23.3.592-599.1979.
4
Pathophysiological effects of Vibrio cholerae and enterotoxigenic Escherichia coli and their exotoxins on eucaryotic cells.霍乱弧菌和产肠毒素大肠杆菌及其外毒素对真核细胞的病理生理作用。
Microbiol Rev. 1978 Sep;42(3):592-613. doi: 10.1128/mr.42.3.592-613.1978.
本文引用的文献
1
Enterotoxigenic Escherichia coli isolated from patients with severe cholera-like disease.从患有严重霍乱样疾病的患者中分离出的产肠毒素大肠杆菌。
J Infect Dis. 1971 Apr;123(4):378-85. doi: 10.1093/infdis/123.4.378.
2
Tissue-culture assay of antibodies to heat-labile Escherichia coli enterotoxins.对不耐热大肠杆菌肠毒素抗体的组织培养测定
N Engl J Med. 1974 Jul 18;291(3):117-21. doi: 10.1056/NEJM197407182910302.
3
Antitoxin responses to infections with enterotoxigenic Escherichia coli.针对产肠毒素大肠杆菌感染的抗毒素反应。
J Infect Dis. 1974 Mar;129(3):330-5. doi: 10.1093/infdis/129.3.330.
4
Detection of heat-labile Escherichia coli enterotoxin with the use of adrenal cells in tissue culture.利用组织培养中的肾上腺细胞检测不耐热大肠杆菌肠毒素。
Science. 1974 Jan 25;183(4122):334-6. doi: 10.1126/science.183.4122.334.
5
Identification of enterotoxigenic Escherichia coli and serum antitoxin activity by the vascular permeability factor assay.通过血管通透性因子测定法鉴定产肠毒素大肠杆菌及血清抗毒素活性
Infect Immun. 1973 Nov;8(5):731-5. doi: 10.1128/iai.8.5.731-735.1973.
6
Cyclic adenosine monophosphate and alteration of Chinese hamster ovary cell morphology: a rapid, sensitive in vitro assay for the enterotoxins of Vibrio cholerae and Escherichia coli.环磷酸腺苷与中国仓鼠卵巢细胞形态改变：一种用于检测霍乱弧菌和大肠杆菌肠毒素的快速、灵敏的体外测定法。
Infect Immun. 1974 Aug;10(2):320-7. doi: 10.1128/iai.10.2.320-327.1974.
7
Immunological study of the heat-labile enterotoxins of Escherichia coli and Vibrio cholerae.大肠杆菌和霍乱弧菌不耐热肠毒素的免疫学研究。
Infect Immun. 1974 Mar;9(3):564-70. doi: 10.1128/iai.9.3.564-570.1974.
8
Editorial: Gastroenterologists on the move: the nature of travelers' diarrhea.
N Engl J Med. 1976 Jun 10;294(24):1340-1. doi: 10.1056/NEJM197606102942409.
9
Antibodies to heat-labile Escherichia coli enterotoxin in Apaches in Whiteriver, Arizona.亚利桑那州怀特河阿帕奇人血清中针对不耐热大肠杆菌肠毒素的抗体
Infect Immun. 1975 Dec;12(6):1475-7. doi: 10.1128/iai.12.6.1475-1477.1975.
10
Human diarrheal disease caused by enterotoxigenic Escherichia coli.由产肠毒素大肠杆菌引起的人类腹泻病。
Annu Rev Microbiol. 1975;29:333-53. doi: 10.1146/annurev.mi.29.100175.002001.
Zotero 插件