使用自发交替Y迷宫试验评估老年雄性小鼠的空间工作记忆。
Assessing Spatial Working Memory Using the Spontaneous Alternation Y-maze Test in Aged Male Mice.
作者信息
Prieur Emily A K, Jadavji Nafisa M
机构信息
Department of Neuroscience, Carleton University, Ottawa, Canada.
出版信息
Bio Protoc. 2019 Feb 5;9(3):e3162. doi: 10.21769/BioProtoc.3162.
Abstract
The global population is aging and the prevalence of age-related diseases, such as Alzheimer's disease and vascular dementia is increasing. Understanding functional impairments and disease processes is of vital importance in order to develop effective therapeutics. Using the natural exploratory behavior of mice, the spontaneous alternation y-maze can assess short-term spatial working memory. The protocol for y-maze testing is straightforward and requires minimal resources, as well as animal training and output. Therefore, it can be broadly applied to study short-term memory in aged rodent models.
摘要
全球人口正在老龄化，阿尔茨海默病和血管性痴呆等与年龄相关疾病的患病率正在上升。为了开发有效的治疗方法，了解功能障碍和疾病过程至关重要。利用小鼠的自然探索行为，自发交替Y迷宫可以评估短期空间工作记忆。Y迷宫测试方案简单明了，所需资源、动物训练和产出最少。因此，它可广泛应用于研究老年啮齿动物模型中的短期记忆。
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