Shomo R E, Chandrasekaran A, Marshall A G, Reuning R H, Robertson L W
Department of Chemistry, College of Pharmacy, Columbus, Ohio 43210.
Biomed Environ Mass Spectrom. 1988 Mar 1;15(5):295-302. doi: 10.1002/bms.1200150510.
Mass spectra of digoxin and digitoxin (the most widely prescribed drugs for treatment of congestive heart failure) and a complete set of their 14 dihydro- and sugar-hydrolyzed metabolites have been obtained via laser desorption/ionization with a Fourier transform ion cyclotron resonance (LD/FT/ICR) mass spectrometer. The most intense peak is typically the pseudomolecular [M + K]+ ion, but fragment ions corresponding to loss of 1-3 sugars and hydroxyls are also observed. LD/FT/ICR mass spectra for all 16 compounds were produced with a single set of sample and spectrometer parameters. No matrix peaks are present. Finally, LD/FT/ICR provides dynamic mass accuracy within approximately 5 ppm throughout a mass range of 404 less than m/z less than 819.
通过傅里叶变换离子回旋共振激光解吸/电离（LD/FT/ICR）质谱仪获得了地高辛和洋地黄毒苷（治疗充血性心力衰竭最常用的药物）及其14种二氢和糖水解代谢产物的质谱图。最强的峰通常是准分子[M + K]+离子，但也观察到了对应于1-3个糖和羟基损失的碎片离子。所有16种化合物的LD/FT/ICR质谱图均采用一组样品和光谱仪参数生成。不存在基质峰。最后，在404小于m/z小于819的质量范围内，LD/FT/ICR在整个范围内提供约5 ppm的动态质量精度。
