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密歇根州西南部首例莱姆病性心肌炎病例报告。

First reported case of Lyme carditis in Southwest Michigan.

作者信息

Frazier Nicholas M, Douce Richard W

机构信息

Internal Medicine Resident, Lakeland Regional Medical Center, Saint Joseph, MI.

Core Faculty and Attending Physician Infectious Diseases/Internal Medicine, Lakeland Regional Medical Center, Saint Joseph, MI.

出版信息

Spartan Med Res J. 2017 Feb 2;1(2):5933. doi: 10.51894/001c.5933.

Abstract

Lyme disease is the most common tick-borne infection found in the eastern United States. In recent years, it has become an emergent Michigan public health concern. Lyme carditis is a recognized rare complication which is classically characterized by rapidly fluctuating degrees of heart block. In severe cases, or if inappropriately treated, Lyme carditis can also result in profound bradycardia, perimyocarditis, and sudden cardiac death. This report describes the first documented case of third degree heart block associated with Lyme carditis to occur in Michigan. This is a retrospective case report of a patient evaluated and treated for Lyme carditis in Southwest Michigan in July, 2016. All information was obtained from either the patient or his electronic medical record. Despite initial misdiagnosis and inappropriate management, this patient ultimately received more appropriate medical therapy within 24 hours of first presentation. After eight days of high dose intravenous Ceftriaxone and supportive care, and more than two weeks of oral Doxycycline, the patient's symptoms resolved and the disease was treated to resolution. Neither permanent nor temporary pacing was needed during/after the course of treatment. When correctly identified, Lyme disease and Lyme carditis can be easily treated. Although this patient's history was without reported tick bite or exposure to a known host for Lyme disease, the authors believe that the patient's history and physical exam was definitive enough to warrant the start of IV therapy with telemetry monitoring upon first presentation. The fact that the condition was not first diagnosed by providers indicates a potential gap in medical knowledge and awareness that should be addressed in clinical practice. The authors consider this case a harbinger of the emerging disease of Lyme carditis. Physical exam and EKG findings should guide clinicians' therapeutic approaches. Although treatment with appropriate antibiotics is typically curative, therapeutic delays can lead to deadly results.

摘要

莱姆病是美国东部最常见的蜱传播感染疾病。近年来,它已成为密歇根州一个新出现的公共卫生问题。莱姆心肌炎是一种公认的罕见并发症,其典型特征是心脏传导阻滞程度迅速波动。在严重病例中,或者如果治疗不当,莱姆心肌炎还可导致严重心动过缓、心包心肌炎和心源性猝死。本报告描述了密歇根州首例有记录的与莱姆心肌炎相关的三度心脏传导阻滞病例。这是一份回顾性病例报告,讲述了一名于2016年7月在密歇根州西南部接受莱姆心肌炎评估和治疗的患者。所有信息均来自患者本人或其电子病历。尽管最初诊断错误且治疗不当,但该患者在首次就诊后24小时内最终接受了更合适的药物治疗。经过8天的大剂量静脉注射头孢曲松和支持治疗,以及两周多的口服多西环素治疗后,患者症状消失,疾病得到治愈。治疗期间/之后均无需进行永久性或临时性起搏。当正确识别时,莱姆病和莱姆心肌炎很容易治疗。尽管该患者的病史中未报告有蜱叮咬或接触过已知的莱姆病宿主,但作者认为患者的病史和体格检查足以明确诊断,因此在首次就诊时就应开始进行遥测监测下的静脉治疗。提供者最初未诊断出该疾病这一事实表明医学知识和意识方面存在潜在差距,临床实践中应加以解决。作者认为该病例是莱姆心肌炎这一新兴疾病的一个先兆。体格检查和心电图结果应指导临床医生的治疗方法。尽管使用适当的抗生素治疗通常可以治愈,但治疗延迟可能导致致命后果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c38/7746127/91494fc291de/smrj_2017_1_2_5933_16027.jpg

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