School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, PR China.
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, PR China.
J Drug Target. 2021 Sep;29(8):900-909. doi: 10.1080/1061186X.2021.1892117. Epub 2021 Mar 3.
Drug delivery with the help of nanoparticles could transport more payloads to tumour site. Owing to their limited accumulation and penetration in the tumour tissues, to increase delivery efficiency is currently still required for applying nanomedicine to treat tumour. Here, we initially report a pressure-driven accumulation of drug-loaded nanoparticles to tumours for efficient tumour therapy with a dry cupping device. The mesoporous Mn-doped silica based nanoparticles delivering 5-aza-2-deoxycytidine and docetaxel were prepared, characterised and used as a model nanomedicine to investigate the potential of dry cupping treatment. For this system, the Mn doping not only endowed the mesoporous silica nanoparticles biodegradability, but also made it much easier to bind a tumour targeting group, which is a G-quadruplex-forming aptamer AS1411. On tumour-bearing mice, the results demonstrated that the dry cupping treatment could substantially improve the distribution of nanomedicines at tumour site, resulting in enhanced treatment efficacy. Overall, this method enables the therapeutical nanoparticles accumulate to tumour through increasing the blood perfusion as well as altering the biological barrier, which opened up possibilities for the development of pressure-driven nanomedicine accumulation at tumour site.
借助纳米颗粒进行药物输送可以将更多的有效载荷输送到肿瘤部位。由于纳米颗粒在肿瘤组织中的积累和渗透有限，为了提高递送效率，目前仍然需要将纳米医学应用于肿瘤治疗。在这里，我们首次报告了一种使用干式拔罐装置将载药纳米颗粒压积到肿瘤部位，以实现高效的肿瘤治疗。我们制备、表征了负载 5-氮杂-2-脱氧胞苷和多西紫杉醇的介孔 Mn 掺杂二氧化硅基纳米颗粒，并将其用作模型纳米药物来研究干式拔罐治疗的潜力。对于该系统，Mn 掺杂不仅赋予了介孔二氧化硅纳米颗粒的生物降解性，而且还使得更容易结合肿瘤靶向基团，即 G-四链体形成适体 AS1411。在荷瘤小鼠上的实验结果表明，干式拔罐治疗可以显著改善纳米药物在肿瘤部位的分布，从而增强治疗效果。总的来说，这种方法通过增加血液灌注和改变生物屏障，使治疗性纳米颗粒能够积聚到肿瘤部位，为开发压力驱动的肿瘤部位纳米药物积聚开辟了可能性。
