Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, India.
Curr Drug Deliv. 2022;19(2):229-237. doi: 10.2174/1567201818666210224101456.
At present, treatment methods for cancer are limited, partially due to the solubility, poor cellular distribution of drug molecules and the incapability of drugs to cross the cellular barriers. Carbon Nanotubes (CNTs) generally have excellent physio-chemical properties, which include High-level penetration into the cell membrane, high surface area, and high capacity of drug-loading by circulating modification with biomolecules, projecting them as an appropriate candidate to diagnose and deliver drugs to Prostate Cancer (PCa). Additionally, the chemically modified CNTs possess excellent 'biosensing' properties, thus helping them detect the PCa easily without a fluorescent agent and additionally, targeting the particular site of PCa. In this way, drug delivery can accomplish high efficacy, enhanced permeability with less toxic effects. While CNTs have been mainly engaged in cancer treatment, a few studies are focused on the diagnosis and treatment of PCa. Here, we have meticulously reviewed the current progress of the CNTs-based diagnosis and the targeted drug delivery system for managing and curing PCa.
目前,癌症的治疗方法有限,部分原因是药物分子的溶解性差、细胞内分布不良以及药物无法穿透细胞屏障。碳纳米管(CNTs)通常具有出色的物理化学性质,包括高水平穿透细胞膜、高表面积和通过循环修饰与生物分子结合的高载药能力,使它们成为诊断和向前列腺癌(PCa)输送药物的合适候选物。此外,经过化学修饰的 CNTs 具有出色的“生物传感”特性,因此有助于它们在没有荧光剂的情况下轻松检测到 PCa,并靶向 PCa 的特定部位。通过这种方式,药物输送可以实现高效、增强的渗透性,同时减少毒性作用。虽然 CNTs 主要用于癌症治疗,但也有一些研究专注于前列腺癌的诊断和治疗。在这里,我们详细回顾了基于 CNTs 的诊断和靶向药物输送系统在管理和治疗 PCa 方面的最新进展。