磁共振波谱分析在鉴别脑内良恶性病变中的准确性。

Accuracy of Magnetic Resonance Spectroscopy in Discrimination of Neoplastic and Non-Neoplastic Brain Lesions.

机构信息

Diagnostic Radiology Department, College of Applied Medical Sciences, University of Hail, Hai', Saudi Arabia.

Diagnostic Radiology Department, College of Applied Medical Sciences, Taibah University, Al-Madinah, Saudi Arabia.

出版信息

Curr Med Imaging. 2021;17(7):904-910. doi: 10.2174/1573405617666210224112808.

DOI:10.2174/1573405617666210224112808

PMID:33655843

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8811616/

Abstract

BACKGROUND

Differentiation of brain lesions by conventional MRI alone is not enough. The introduction of sophisticated imaging methods, such as MR Spectroscopy (MRS), will contribute to accurate differentiation.

OBJECTIVE

To determine the diagnostic accuracy of MRS in differentiating neoplasm and non-neoplastic brain lesion.

METHODOLOGY

This is a cross-sectional descriptive study conducted at Khartoum State from the period of 2015 to 2017. Thirty cases with brain lesions were included in the study investigated with MRS (Single-voxel spectroscopy) and conventional MRI. A comparison of MRS findings and histopathologic analysis was performed. The ratios of Cho/Cr and Cho/NAA were analyzed and compared between neoplastic and non-neoplastic brain masses. Data were analyzed using SPSS version 23.

RESULTS

Out of the 30 patients affected with brain lesions, there were 16 females and 14 males with a mean age of 44 +- 18 years. The ratios of Cho/Cr and Cho/NAA were higher in gliomas, astrocytoma, and meningioma than non-neoplastic lesions. Kappa statistical value (K) showed a good agreement between MRS and histopathological analysis (K= 0.60). The diagnostic accuracy of MRS was 100%, with 82.60% sensitivity, 85.71% specificity, 95% PPV, and 60% NPV.

CONCLUSION

MRS has high diagnostic accuracy in differentiating neoplasm from non-neoplastic brain tumors. The elevation ratios of Choline-to- N-acetyl aspartate and choline-to- creatine can help neurosurgeons and clinicians differentiate benign from malignant masses.

摘要

背景

仅凭常规 MRI 区分脑部病变还不够。引入先进的成像方法，如磁共振波谱（MRS），将有助于准确区分。

目的

确定 MRS 在区分肿瘤和非肿瘤性脑病变方面的诊断准确性。

方法

这是一项在 2015 年至 2017 年期间在喀土穆州进行的横断面描述性研究。30 例脑部病变患者纳入研究，进行 MRS（单体素波谱）和常规 MRI 检查。比较 MRS 结果与组织病理学分析。分析并比较肿瘤性和非肿瘤性脑肿块之间的 Cho/Cr 和 Cho/NAA 比值。使用 SPSS 版本 23 分析数据。

结果

在受脑部病变影响的 30 名患者中，有 16 名女性和 14 名男性，平均年龄为 44+ - 18 岁。在神经胶质瘤、星形细胞瘤和脑膜瘤中，Cho/Cr 和 Cho/NAA 的比值高于非肿瘤性病变。Kappa 统计值（K）显示 MRS 与组织病理学分析之间具有良好的一致性（K=0.60）。MRS 的诊断准确性为 100%，灵敏度为 82.60%，特异性为 85.71%，PPV 为 95%，NPV 为 60%。