Department of Nutrition and Public Health, University of Agder, Universitetsveien 25, 4604 Kristiansand, Norway.
Applied Bioenergetics Lab, Faculty of Sport and PE, University of Novi Sad, 21000 Novi Sad, Serbia.
Nutrients. 2022 Mar 15;14(6):1230. doi: 10.3390/nu14061230.
Low tissue creatine characterizes many conditions, including neurodegenerative, cardiopulmonary, and metabolic diseases, with a magnitude of creatine shortfall often corresponds well to a disorder's severity. A non-invasive monitoring of tissue metabolism with magnetic resonance spectroscopy (MRS) might be a feasible tool to evaluate suboptimal levels of creatine for both predictive, diagnostic, and therapeutic purposes. This mini review paper summarizes disorders with deficient creatine levels and provides arguments for assessing and employing tissue creatine as a relevant target in clinical nutrition.
低组织肌酸特征存在于多种病症中，包括神经退行性、心肺和代谢疾病，肌酸缺乏的严重程度通常与疾病的严重程度相当。磁共振波谱（MRS）的组织代谢非侵入性监测可能是一种可行的工具，可用于评估肌酸水平不足，无论是用于预测、诊断还是治疗目的。本文综述了肌酸水平不足的疾病，并提出了评估和利用组织肌酸作为临床营养相关靶点的依据。
