Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France.
CIC1401-EC, Inserm, Bordeaux, France.
Alzheimers Dement. 2021 Sep;17(9):1415-1421. doi: 10.1002/alz.12308. Epub 2021 Mar 3.
Studies on the association of cancer and risk of dementia are inconclusive due to result heterogeneity and concerns of survivor bias and unmeasured confounding.
This study uses data from the Memento cohort, a French multicenter cohort following persons with either mild or isolated cognitive complaints for a median of 5 years. Illness-death models (IDMs) were used to estimate transition-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for incident cancer in relation to dementia from time since study entry.
The analytical sample (N = 2258) excluded 65 individuals without follow-up information. At the end of follow-up, 286 individuals were diagnosed with dementia, 166 with incident cancer, and 95 died. Incident cancer was associated with a reduced risk of dementia (HR = 0.58, 95% CI = 0.35-0.97), with a corresponding E-value of 2.84 (lower CI = 1.21).
This study supports a protective relationship between incident cancer and dementia, encouraging further investigations to understand potential underlying mechanisms.
由于结果异质性以及对幸存者偏差和未测量混杂因素的担忧，癌症与痴呆风险关联的研究尚无定论。
本研究使用了 Memento 队列的数据，这是一个法国多中心队列，对有轻度或孤立性认知主诉的患者进行了中位数为 5 年的随访。采用疾病死亡模型（IDM）来估计从研究开始到痴呆的特定时间癌症发病的风险比（HR）和 95%置信区间（CI）。
分析样本（N=2258）排除了 65 名无随访信息的个体。随访结束时，286 人被诊断为痴呆，166 人患有新发癌症，95 人死亡。新发癌症与痴呆风险降低相关（HR=0.58，95%CI=0.35-0.97），相应的 E 值为 2.84（下 CI=1.21）。
本研究支持新发癌症与痴呆之间存在保护关系，鼓励进一步研究以了解潜在的机制。
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