癌症与阿尔茨海默病风险：全国队列研究中的小关联。
Cancer and risk of Alzheimer's disease: Small association in a nationwide cohort study.
机构信息
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA.
出版信息
Alzheimers Dement. 2020 Jul;16(7):953-964. doi: 10.1002/alz.12090. Epub 2020 May 20.
INTRODUCTION
Small observational studies with short-term follow-up suggest that cancer patients are at reduced risk of Alzheimer's disease (AD) compared to the general population.
METHODS
A nationwide cohort study using Danish population-based health registries (1980-2013) with cancer patients (n = 949,309) to identify incident diagnoses of AD. We computed absolute reductions in risk attributed to cancer and standardized incidence rate ratios (SIRs) accounting for survival time, comparing the observed to expected number of AD cases.
RESULTS
During up to 34 years of follow-up of cancer survivors, the attributable risk reduction was 1.3 per 10,000 person-years, SIR = 0.94 (95% confidence interval 0.92-0.96). SIRs were similar after stratification by sex, age, and cancer stage, and approached that of the general population for those surviving >10 years.
DISCUSSION
Inverse associations between cancer and AD were small and diminished over time. Incidence rates in cancer survivors approached those of the general population, suggesting limited association between cancer and AD risk.
简介
短期随访的小型观察性研究表明，与一般人群相比，癌症患者患阿尔茨海默病（AD）的风险较低。
方法
一项全国性的队列研究利用丹麦基于人群的健康登记系统（1980-2013 年），对癌症患者（n=949309 人）进行 AD 的确诊病例进行了识别。我们计算了归因于癌症的风险绝对减少量，并考虑了生存时间的标准化发病率比（SIRs），比较了观察到的和预期的 AD 病例数量。
结果
在癌症幸存者长达 34 年的随访期间，归因于风险的减少量为每 10000 人年 1.3 例，SIR=0.94（95%置信区间 0.92-0.96）。按性别、年龄和癌症分期分层后，SIR 相似，且对于生存时间>10 年的患者，SIR 接近一般人群。
讨论
癌症与 AD 之间呈负相关，且随着时间的推移而减弱。癌症幸存者的发病率接近一般人群，这表明癌症与 AD 风险之间的关联有限。
Zotero 插件