Kollarigowda Ravichandran H, Braun Paul V
Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
J Org Chem. 2021 Mar 19;86(6):4391-4397. doi: 10.1021/acs.joc.0c02375. Epub 2021 Mar 3.
Here, we report a solid-phase approach to synthesize azobenzene and spiropyran derivatives. The divergent synthesis process requires no purification steps to obtain the desired product with a 28-55% yield, depending on the specific compound. For the spiropyran compounds, solid-phase resin cleavage is performed under mild conditions to minimize spiropyran ring opening. The solid-phase method enables the synthesis of a library of azobenzene and spiropyran derivatives without the need to develop purification strategies for each derivative.
在此，我们报告一种合成偶氮苯和螺吡喃衍生物的固相方法。这种发散式合成过程无需纯化步骤即可获得所需产物，产率在28%至55%之间，具体取决于特定化合物。对于螺吡喃化合物，在温和条件下进行固相树脂裂解，以尽量减少螺吡喃环的开环。固相方法能够合成偶氮苯和螺吡喃衍生物库，而无需为每种衍生物制定纯化策略。
