Furuta Y, Hunter N, Barkley T, Hall E, Milas L
Department of Experimental Radiotherapy, University of Texas M. D. Anderson Hospital and Tumor Institute, Houston 77030.
Cancer Res. 1988 Jun 1;48(11):3008-13.
Indomethacin, an inhibitor of prostaglandin (PG) synthesis, was investigated for its ability to increase radioresponse of two fibrosarcomas, FSA and NFSA, in C3Hf/Kam mice. In addition, the effect of indomethacin on radioresponse of hematopoietic tissue, jejunum, hair follicles, and tissues involved in the development of radiation-induced leg contractures was determined. Indomethacin greatly increased radioresponse of 8-mm tumors, as assessed by both tumor growth delay and TCD50 assays. Enhancement factors for tumor growth delay and tumor radiocurability (TCD50) were 1.55 and 1.39, respectively, for FSA, and 1.4 and 1.26, respectively, for NFSA tumors. Of four normal tissues assessed, two (hair follicles and tissues responsible for development of leg contractures) showed no change in radioresponse after treatment with indomethacin, one (hematopoietic tissue) exhibited radioprotection, and one (jejunum) exhibited slight radiosensitization (enhancement factor, 1.12). Therefore, indomethacin significantly augmented tumor radiocurability but had minimal effect on radioresponse of some normal tissues.
吲哚美辛是一种前列腺素（PG）合成抑制剂，研究了其增强C3Hf/Kam小鼠体内两种纤维肉瘤FSA和NFSA放射反应的能力。此外，还确定了吲哚美辛对造血组织、空肠、毛囊以及与放射性腿部挛缩发展相关组织放射反应的影响。通过肿瘤生长延迟和TCD50测定评估，吲哚美辛显著增强了8毫米肿瘤的放射反应。FSA肿瘤生长延迟和肿瘤放射治愈率（TCD50）的增强因子分别为1.55和1.39，NFSA肿瘤分别为1.4和1.26。在评估的四种正常组织中，两种（毛囊和导致腿部挛缩的组织）在吲哚美辛治疗后放射反应无变化，一种（造血组织）表现出放射保护作用，一种（空肠）表现出轻微的放射增敏作用（增强因子为1.12）。因此，吲哚美辛显著提高了肿瘤放射治愈率，但对一些正常组织的放射反应影响最小。
