Department of Radiopharmaceutical and Chemical Biology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstrasse 400, Dresden D-01328, Germany.
Department of Chemistry and Food Chemistry, Technische Universität Dresden, Dresden D-01062, Germany.
Antioxidants (Basel). 2016 Apr 19;5(2):14. doi: 10.3390/antiox5020014.
Radiation therapy (RT) evolved to be a primary treatment modality for cancer patients. Unfortunately, the cure or relief of symptoms is still accompanied by radiation-induced side effects with severe acute and late pathophysiological consequences. Inhibitors of cyclooxygenase-2 (COX-2) are potentially useful in this regard because radioprotection of normal tissue and/or radiosensitizing effects on tumor tissue have been described for several compounds of this structurally diverse class. This review aims to substantiate the hypothesis that antioxidant COX-2 inhibitors are promising radioprotectants because of intercepting radiation-induced oxidative stress and inflammation in normal tissue, especially the vascular system. For this, literature reporting on COX inhibitors exerting radioprotective and/or radiosensitizing action as well as on antioxidant COX inhibitors will be reviewed comprehensively with the aim to find cross-points of both and, by that, stimulate further research in the field of radioprotective agents.
放射治疗（RT）已发展成为癌症患者的主要治疗方式。不幸的是，治愈或缓解症状仍然伴随着放射性副作用，这些副作用具有严重的急性和晚期病理生理后果。环氧化酶-2（COX-2）抑制剂在这方面可能很有用，因为已经描述了该结构多样的化合物类别的几种化合物对正常组织具有放射防护作用和/或对肿瘤组织具有放射增敏作用。本综述旨在证实以下假设，即抗氧化 COX-2 抑制剂是有前途的放射防护剂，因为它们可以阻断正常组织（特别是血管系统）中的辐射诱导的氧化应激和炎症。为此，将全面回顾有关 COX 抑制剂发挥放射防护和/或放射增敏作用以及抗氧化 COX 抑制剂的文献，旨在找到两者的交点，并以此激发放射防护剂领域的进一步研究。
