Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
NAFLD Research Center, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Cell Metab. 2021 Mar 2;33(3):457. doi: 10.1016/j.cmet.2021.02.013.
Oh et al. address concerns about the influence of proton pump inhibitor (PPI) use on a gut microbiome signature for cirrhosis. By removing PPI using subjects from the training cohort and retraining a 19-species Random Forest model, they demonstrate the impact of PPI usage on the signature's diagnostic accuracy is minimal.
哦等人解决了质子泵抑制剂 (PPI) 使用对肝硬化肠道微生物组特征影响的问题。他们从训练队列中去除 PPI 使用的受试者，并重新训练一个 19 种物种的随机森林模型，证明了 PPI 使用对特征诊断准确性的影响很小。
