National Centre of Excellence in Analytical Chemistry, University of Sindh, 76080 Jamshoro, Pakistan.
M.A. Kazi Institute of Chemistry, University of Sindh, 76080 Jamshoro, Pakistan.
Langmuir. 2021 Mar 16;37(10):3214-3222. doi: 10.1021/acs.langmuir.1c00165. Epub 2021 Mar 3.
2,4,6-Trichlorophenol (2,4,6 TCP) is one of the hazardous toxicants, which has severe impacts on the environment and human health. This study is designed to develop a highly sensitive and selective electrochemical sensor based on CuO nanostructures for the detection of 2,4,6 TCP. The CuO nanostructures were synthesized through an aqueous chemical growth method and characterized by versatile analytical techniques, for example, Fourier transform infrared spectroscopy, field emission scanning electron microscopy, atomic force microscopy, energy-dispersive spectrometry, and X-ray diffraction. The characterization tools revealed a high crystalline nature, exceptional phase purity, nanoball morphology with an average size of around 18.7 nm for the CuO nanostructures. The synthesized material was used to modify a glassy carbon electrode (GCE) with the help of Nafion as a binder to improve its efficiency and sensitivity. The CuO/Nafion/GCE was proven to be a potential sensor for the determination of 2,4,6 TCP under optimized conditions at a scan rate of 70 mV/s, potential range of 0.1-1.0 V, and phosphate buffer of neutral pH as the supporting electrolyte. The linear range for 2,4,6 TCP was set from (1 to 120 μM) with a low limit of detection value calculated to be 0.046 μM. The developed sensor was effectively applied for water samples with acceptable recovery values from 95.9 to 100.6%.
2,4,6-三氯苯酚（2,4,6 TCP）是一种危险的有毒物质，对环境和人类健康有严重影响。本研究旨在开发一种基于氧化铜纳米结构的高灵敏度和选择性电化学传感器，用于检测 2,4,6 TCP。氧化铜纳米结构通过水相化学生长法合成，并通过多种分析技术进行了表征，例如傅里叶变换红外光谱、场发射扫描电子显微镜、原子力显微镜、能谱和 X 射线衍射。这些表征工具揭示了氧化铜纳米结构具有高结晶性、出色的相纯度、纳米球形态，平均粒径约为 18.7nm。合成的材料被用于通过 Nafion 作为粘合剂修饰玻碳电极（GCE），以提高其效率和灵敏度。在优化条件下，CuO/Nafion/GCE 在扫描速率为 70mV/s、电位范围为 0.1-1.0V、中性 pH 的磷酸盐缓冲液作为支持电解质的条件下，被证明是一种用于测定 2,4,6 TCP 的潜在传感器。2,4,6 TCP 的线性范围设定为（1 至 120 μM），检测下限计算值为 0.046 μM。该开发的传感器有效地应用于水样，回收率从 95.9%到 100.6%之间。
