Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, People's Republic of China.
State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, People's Republic of China.
Emerg Microbes Infect. 2021 Dec;10(1):497-506. doi: 10.1080/22221751.2021.1899056.
HIV-1 CRF08_BC has become a major epidemic in heterosexuals and intravenous drug users (IDUs) in southern China. In order to evaluate the trends of its epidemic and facilitate targeted HIV prevention, we constructed the genetic transmission networks based on its sequences, derived from the National HIV Molecular Epidemiology Survey. Through retrospective network analysis, to study the epidemiological and demographic correlations with the transmission network. Of the 1,829 study subjects, 639 (34.9%) were clustered in 151 transmission networks. Factors associated with increased clustering include IDUs, heterosexual men, young adults and people with lower education ( < 0.05 for all). The IDUs, MSM, young adult and person with low education had more potential transmission links as well ( < 0.05 for all). The most crossover links were found between heterosexual women and IDUs, with 30.9% heterosexual women linked to IDUs. The crossover links heterosexual women were mainly those with middle age and single ( < 0.001). This study indicated that the HIV-1 CRF08_BC epidemic was still on going in China with more than one third of the infected people clustered in the transmission networks. Meanwhile, the study could help identify the active CRF08_BC spreader in the local community and greatly facilitate précising AIDS prevention with targeted intervention.
HIV-1 CRF08_BC 已成为中国南方异性恋和静脉吸毒者（IDUs）中的主要流行病毒。为了评估其流行趋势并促进有针对性的 HIV 预防，我们根据国家 HIV 分子流行病学调查的序列构建了遗传传播网络。通过回顾性网络分析，研究与传播网络相关的流行病学和人口统计学相关性。在 1829 名研究对象中，639 名（34.9%）聚类在 151 个传播网络中。与聚类增加相关的因素包括 IDUs、异性恋男性、年轻成年人和受教育程度较低的人（所有因素均 <0.05）。IDUs、MSM、年轻成年人和受教育程度较低的人也具有更多的潜在传播联系（所有因素均 <0.05）。在异性恋女性和 IDUs 之间发现了最多的交叉联系，30.9%的异性恋女性与 IDUs 有关。异性恋女性的交叉联系主要是那些处于中年和单身的人（<0.001）。本研究表明，HIV-1 CRF08_BC 在中国仍在流行，超过三分之一的感染者聚类在传播网络中。同时，该研究可以帮助识别当地社区中活跃的 CRF08_BC 传播者，并极大地促进有针对性的干预措施，精确预防艾滋病。
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