Neurology Department, Faculty of Medicine, Mansoura University, Mansoura, Dakahlia, Egypt.
Diagnostic Radiology Department, Faculty of Medicine, Kafrelsheikh University, Kafr Ash Shaykh, Egypt.
Neurol Res. 2021 Jul;43(7):582-590. doi: 10.1080/01616412.2021.1893567. Epub 2021 Mar 4.
: To study the serum lactate level in MS and to explore its correlation with the progression and disability in multiple sclerosis (MS), and the important role of mitochondrial dysfunction in the pathogenesis of MS.: This case-control study included 80 participants, involved 50 MS patients and 30 normal healthy controls. Detailed history taking, complete neurological examination, and clinical evaluation of the disability using the Expanded Disability Status Scale (EDSS) were done for all patients. Level of serum lactate was measured in both groups and was correlated with EDSS, MS subtypes, MRI brain, and MRS findings.: Serum lactate in MS patients was about three and half times higher than serum lactate levels of healthy controls (22.87 ± 5.92 mg/dl versus 6.39 ± 0.9 6.39 ± 0.91, p < 0.001). Importantly, serum lactate values were increased in MS cases with a progressive course compared with MS cases with RR course. Also, there were linearly correlations linking serum lactate levels and the duration of MS (r = 0.342, P = 0.015), relapses numbers (r = 0.335, P = 0.022), and EDSS (r = 0.483, P < 0.001). Also, there were strong positive correlations between serum lactate and Lipid/Lactate (r = 0.461, P = 0.001), periventricular lesion (r = 0.453, P = 0.005), and moderate positive correlations between serum lactate and juxtacortical lesion (r = 0.351, P = 0.02), and infratentorial lesion (r = 0.355, P = 0.02).: Measurement of serum lactate may be helpful in MS and this supports the hypothesis of the critical role of mitochondrial dysfunction and axonal damage in MS.: ClinicalTrials.gov ID: NCT04210960.
研究多发性硬化症（MS）患者的血清乳酸水平，探讨其与 MS 进展和残疾的相关性，以及线粒体功能障碍在 MS 发病机制中的重要作用。
本病例对照研究纳入了 80 名参与者，包括 50 名 MS 患者和 30 名正常健康对照。对所有患者进行详细的病史询问、全面的神经系统检查以及使用扩展残疾状况量表（EDSS）进行残疾临床评估。测量两组患者的血清乳酸水平，并与 EDSS、MS 亚型、MRI 脑和 MRS 结果进行相关性分析。
MS 患者的血清乳酸水平约为健康对照组的 3.5 倍（22.87±5.92 mg/dl 与 6.39±0.91，p<0.001）。重要的是，与 RR 病程的 MS 病例相比，进展性病程的 MS 病例中血清乳酸值升高。此外，血清乳酸水平与 MS 病程时间（r=0.342，P=0.015）、复发次数（r=0.335，P=0.022）和 EDSS（r=0.483，P<0.001）呈线性相关。此外，血清乳酸与脂质/乳酸（r=0.461，P=0.001）、脑室周围病变（r=0.453，P=0.005）之间存在强烈正相关，与皮质下病变（r=0.351，P=0.02）和幕下病变（r=0.355，P=0.02）之间存在中度正相关。
血清乳酸的测量可能有助于 MS 的诊断，这支持了线粒体功能障碍和轴突损伤在 MS 中起关键作用的假说。
NCT04210960。
