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肌脂瘤共存于糖皮质激素和雄激素分泌性肾上腺皮质癌:缓慢且良性的临床病程。

MYELOLIPOMA COEXISTENCE WITH GLUCOCORTICOID AND ANDROGEN SECRETING ADRENOCORTICAL CARCINOMA: SLOW AND BENIGN CLINICAL COURSE.

机构信息

Sakarya University, Medicine Faculty, Department of Internal Medicine, Division of Endocrinology; Sakarya University, Turkey.

Sakarya University, Medicine Faculty, Department of Endocrinology; Sakarya University, Turkey.

出版信息

Georgian Med News. 2021 Jan(310):7-11.

Abstract

We present a case of androgen and glucocorticoid secreting adrenocortical carcinoma with concomitant myelolipoma. A giant adrenal tumor which was initially nonfunctional was reassessed four years later due to the patient's refusal to treat. The patient was a 48-year-old woman with hypertension and acne lesions on the face. Laboratory findings were consistent with glucocorticoid and androgen hypersecretion. Computed tomography revealed a heterogeneously contrasting mass of 145x118x100 mm with lobular contour and soft tissue areas. The patient underwent left laparoscopic transperitoneal adrenalectomy with three port technique. There were no complications in the perioperative period. The resected specimen weighed 850 grams. Pathological findings showed a combination of myelolipoma-adrenal cortical cancer. In the postoperative period, hypertension improved and the hormone panel was normalized. Postoperative computed tomography and PET-CT showed no residual mass and metastasis. Although imaging is compatible with benign masses such as myelolipoma, coexistence of ACC-myelolipoma should be kept in mind and functional evaluation should be performed.

摘要

我们报告一例同时伴有骨髓脂肪瘤的雄激素和糖皮质激素分泌性肾上腺皮质癌。最初为非功能性的巨大肾上腺肿瘤,由于患者拒绝治疗,四年后重新评估。患者为 48 岁女性,有高血压和面部痤疮病变。实验室检查结果符合糖皮质激素和雄激素分泌过多。计算机断层扫描显示混杂对比的质量为 145x118x100mm 有小叶轮廓和软组织区域。患者接受左腹腔镜经腹腔肾上腺切除术和三孔技术。围手术期无并发症。切除标本重 850 克。病理结果显示骨髓脂肪瘤-肾上腺皮质癌的组合。术后高血压改善,激素谱正常。术后计算机断层扫描和 PET-CT 未显示残留肿块和转移。虽然影像学检查与骨髓脂肪瘤等良性肿块相符,但应牢记并存的 ACC-骨髓脂肪瘤,并进行功能评估。

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