急性脑静脉和硬脑膜窦血栓形成时首发癫痫发作的预测因素
Predictors of Presenting Seizures in Acute Cerebral Vein and Dural Sinus Thrombosis.
作者信息
Goyal Gourav, Singh Rambir
机构信息
Department of Neurology, Mahatma Gandhi Medical College and Hospital, Jaipur, India.
Department of Radio-diagnosis, R.N.T MC and MB Hospital, Udaipur, India.
出版信息
J Epilepsy Res. 2020 Dec 31;10(2):74-78. doi: 10.14581/jer.20012. eCollection 2020 Dec.
BACKGROUND AND PURPOSE
Risk of seizure is significantly higher in cerebral vein and dural sinus thrombosis (CVST) compared to other stroke subtypes. There is paucity of literature on predictors of presenting seizures in CVST. This study was designed to investigate the risk and predictors of seizures in CVST at presentation.
METHODS
Total 181 consecutive patients with CVST were retrospectively analyzed.
RESULTS
Total 181 patients with CVST were enrolled (age range, 14 to 96 years; mean age, 34.64±14.66 years). A total of 44 patients had presenting seizures. Younger age (=0.028), involvement of superficial cortical veins (=0.016), presence of hemorrhagic venous infarct (≤0.001) and involvement of frontal lobe (≤0.001) were significantly related to the presenting seizures on the univariate analysis. The hemorrhagic venous infarct (odds ratio [OR], 4.44; 95% confidence interval [CI], 1.89-10.44; =0.001) and involvement of the frontal lobe (OR, 10.66; 95% CI, 4.02-28.29; ≤0.001) were independently associated with the presenting seizures on the multivariate analysis.
CONCLUSIONS
About one fourth of the patients with CVST had presenting seizures. The patients with hemorrhagic venous infarct in the frontal region are more prone to have presenting seizures.
背景与目的
与其他卒中亚型相比，脑静脉和硬脑膜窦血栓形成（CVST）患者癫痫发作的风险显著更高。关于CVST患者首发癫痫发作的预测因素的文献较少。本研究旨在调查CVST患者首发时癫痫发作的风险及预测因素。
方法
对181例连续的CVST患者进行回顾性分析。
结果
共纳入181例CVST患者（年龄范围14至96岁；平均年龄34.64±14.66岁）。共有44例患者首发癫痫发作。单因素分析显示，年龄较小（=0.028）、浅表皮质静脉受累（=0.016）、出血性静脉梗死的存在（≤0.001）以及额叶受累（≤0.001）与首发癫痫发作显著相关。多因素分析显示，出血性静脉梗死（比值比[OR]，4.44；95%置信区间[CI]，1.89 - 10.44；=0.001）和额叶受累（OR，10.66；95%CI，4.02 - 28.29；≤0.001）与首发癫痫发作独立相关。
结论
约四分之一的CVST患者首发癫痫发作。额叶有出血性静脉梗死的患者更易首发癫痫发作。
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