Wang Daxi, Wang Yanqun, Sun Wanying, Zhang Lu, Ji Jingkai, Zhang Zhaoyong, Cheng Xinyi, Li Yimin, Xiao Fei, Zhu Airu, Zhong Bei, Ruan Shicong, Li Jiandong, Ren Peidi, Ou Zhihua, Xiao Minfeng, Li Min, Deng Ziqing, Zhong Huanzi, Li Fuqiang, Wang Wen-Jing, Zhang Yongwei, Chen Weijun, Zhu Shida, Xu Xun, Jin Xin, Zhao Jingxian, Zhong Nanshan, Zhang Wenwei, Zhao Jincun, Li Junhua, Xu Yonghao
BGI-Shenzhen, Shenzhen, China.
Shenzhen Key Laboratory of Unknown Pathogen Identification, BGI-Shenzhen, Shenzhen, China.
Front Med (Lausanne). 2021 Feb 15;8:585358. doi: 10.3389/fmed.2021.585358. eCollection 2021.
The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions.
新型人类冠状病毒SARS-CoV-2的出现引发了全球新型冠状病毒肺炎（COVID-19，即2019冠状病毒病）大流行。在此，我们对新型冠状病毒肺炎患者家庭内部和不同家庭之间的SARS-CoV-2病毒群体进行了特征分析和比较。我们的研究表明，该病毒在人类呼吸道中具有活跃的复制活性，并且同一宿主内存在基因不同的病毒。对病毒群体的宿主间比较进一步揭示，来自同一家庭的患者之间的传播瓶颈较窄，这表明随机动力学在宿主间和宿主体内进化中均起主导作用。
