纤维蛋白降解试验
Fibrin Breakdown Assay.
作者信息
Ling Jiayue, Blair Connor M, Baillie George S
机构信息
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
出版信息
Bio Protoc. 2020 Apr 20;10(8):e3585. doi: 10.21769/BioProtoc.3585.
Fibrinolysis is an integral part of the matrix remodeling process that contributes to tissue repair. Fibrin clots are broken down during fibrinolysis in a controlled process. Fibrin degradation products (FDPs) have also been shown to have a role in the regulation of cell growth and are implicated in various vascular diseases. This protocol was designed to quantitatively measure the extent of fibrin breakdown and how this can be adapted as a tool to further investigate the pathway involved in fibrinolysis or fibrin degradation products. Until now, we haven't found an alternative method to analysis fibrinolysis.
纤维蛋白溶解是基质重塑过程中不可或缺的一部分，有助于组织修复。在可控的纤维蛋白溶解过程中，纤维蛋白凝块会被分解。纤维蛋白降解产物（FDPs）也已被证明在细胞生长调节中发挥作用，并与多种血管疾病有关。本方案旨在定量测量纤维蛋白分解的程度，以及如何将其作为一种工具，进一步研究纤维蛋白溶解或纤维蛋白降解产物所涉及的途径。到目前为止，我们尚未找到分析纤维蛋白溶解的替代方法。
Zotero 插件