Departments of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (CRG), Translational Biomarkers (AG, EM), Merck & Co., Inc., West Point, PA, USA.
Pharmacol Res Perspect. 2021 Apr;9(2):e00731. doi: 10.1002/prp2.731.
This short report describes the measurement of total liver blood flow in commonly used laboratory rats using the relatively non-invasive approach of ultrasound imaging. A total of 29 rats (n = 26 Wistar-Han, n = 3 Sprague-Dawley) were imaged and both male and female rats were included. The mean (SD) total liver blood flow of all animals combined was 33.3 ± 7.8 mL/min, or 104.3 ± 17.1 mL/min/kg when normalized to observed body weight at the time of imaging. There was a trend for higher unnormalized total liver blood flow as body weight increased and the female rats had, in general, the lowest body weight and total liver blood flow of the animals studied. There were no major differences in total liver blood flow between the small number of Sprague-Dawley rats used in the study and the larger Wistar-Han group. Further research would be needed to accurately characterize any subtle differences in body weight between rats of different strains, sexes, and body weight.
本短讯描述了使用相对非侵入性的超声成像技术测量常用实验大鼠的总肝血流量。共对 29 只大鼠（n=26 只 Wistar-Han，n=3 只 Sprague-Dawley）进行了成像，包括雄性和雌性大鼠。所有动物的平均（SD）总肝血流量为 33.3±7.8 mL/min，或在标准化为成像时观察到的体重时为 104.3±17.1 mL/min/kg。未校正的总肝血流量随体重增加而呈上升趋势，而雌性大鼠的体重和总肝血流量通常是研究动物中最低的。研究中使用的少量 Sprague-Dawley 大鼠与较大的 Wistar-Han 大鼠组之间的总肝血流量无明显差异。需要进一步研究以准确描述不同品系、性别和体重的大鼠之间体重的任何细微差异。
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