Department of Materials Science, Graduate School of Pure and Applied Science, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan.
Faculty of Health and Sport Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki, 305-8574, Japan.
Adv Healthc Mater. 2021 May;10(10):e2100067. doi: 10.1002/adhm.202100067. Epub 2021 Mar 4.
Although the adverse effects of excessively generated reactive oxygen species (ROS) on the body during aerobic exercise have been debated, there are few reports on the remarkable effects of the application of conventional antioxidants on exercise performance. The conventional antioxidants could not enhance exercise performance due to their rapid excretion from the body and serious adverse effects on the cellular respiratory system. In this study, impact of the original antioxidant self-assembling nanoparticle, redox-active nanoparticle (RNP), is investigated on the exercise performance of rats during running experiments. With an increase in the dose of the administered RNP, the all-out time of the rat running extends in a dose-dependent manner. In contrast, with an increase in the dose of the low-molecular-weight (LMW) antioxidant, the all-out running time of the rats decreases. The control group and LMW antioxidant treated group decrease in the number of red blood cells (RBCs) and increase oxidative stress after running. However, the RNP group maintains a similar RBC level and oxidative stress as that of the sedentary group. The results suggest that RNP, which shows long-blood circulation without disturbance of mitohormesis, effectively removes ROS from the bloodstream to suppresses RBC oxidative stress and damage, thus improving exercise performance.
虽然在有氧运动过程中，过多产生的活性氧（ROS）对身体的不良影响一直存在争议，但关于常规抗氧化剂对运动表现的显著影响的报道却很少。由于常规抗氧化剂从体内迅速排出，并且对细胞呼吸有严重的副作用，因此无法增强运动表现。在这项研究中，研究了原始抗氧化剂自组装纳米颗粒，氧化还原活性纳米颗粒（RNP），对大鼠在跑步实验中运动表现的影响。随着给予的 RNP 剂量的增加，大鼠的全力奔跑时间呈剂量依赖性延长。相比之下，随着低分子量（LMW）抗氧化剂剂量的增加，大鼠的全力奔跑时间减少。与对照组和 LMW 抗氧化剂处理组相比，运动后红细胞（RBC）数量减少，氧化应激增加。然而，RNP 组的 RBC 水平和氧化应激与安静组相似。结果表明，RNP 具有长血液循环而不干扰线粒体适应，可有效从血液中清除 ROS，抑制 RBC 氧化应激和损伤，从而提高运动表现。
