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Genetic factors involved in human G gamma and A gamma globin gene expression.

作者信息

Bouhass R, Taleb-Bendiab R, Starck J, Morle F, Aguercif M, Godet J

机构信息

Institut National d'Etudes Supérieures en Sciences Médicales, Service de Pédiatrie, Centre Emir Abdelkader, Oran, Algérie.

出版信息

Eur J Haematol. 1988 Apr;40(4):350-4. doi: 10.1111/j.1600-0609.1988.tb00190.x.

DOI:10.1111/j.1600-0609.1988.tb00190.x
PMID:3366225
Abstract

G gamma to A gamma globin ratios, haplotypes at the beta globin gene cluster and the C----T substitution at -158 5' to the G gamma globin gene were studied in three Algerian families that include SS or S-beta(0) thal patients. G gamma to A gamma ratios were found similar, within a family, in subjects displaying the same combination of chromosomes 11, the ratio observed for a given combination depending on the chromosome haplotypes. Our data can be explained by the existence of several alleles of a genetic factor closely linked to the beta globin gene cluster and involved in the determination of G gamma to A gamma globin ratio.

摘要

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