胆固醇负荷兔肝细胞原代培养中极低密度脂蛋白载脂蛋白分泌及载脂蛋白B信使核糖核酸水平
VLDL apoprotein secretion and apo-B mRNA level in primary culture of cholesterol-loaded rabbit hepatocytes.
作者信息
Kosykh V A, Surguchov A P, Podres E A, Novikov D K, Sudarickov A B, Repin V S, Smirnov V N
机构信息
USSR Cardiology Research Center, Academy of Medical Sciences, Moscow.
出版信息
FEBS Lett. 1988 May 9;232(1):103-6. doi: 10.1016/0014-5793(88)80395-8.
Incubation of cultured rabbit hepatocytes with beta very low density lipoproteins (beta-VLDL) induces a dose-dependent increase in cell cholesterol (CH) content and VLDL apoprotein (apo) B and E secretion without change in apo-B mRNA level. These data suggest that beta-VLDL may exert a stimulatory effect on hepatic apo-B production at the co-translational and/or posttranslational level.
用β极低密度脂蛋白（β-VLDL）孵育培养的兔肝细胞，可导致细胞胆固醇（CH）含量呈剂量依赖性增加，VLDL载脂蛋白（apo）B和E分泌增加，而apo-B mRNA水平无变化。这些数据表明，β-VLDL可能在共翻译和/或翻译后水平对肝脏apo-B的产生发挥刺激作用。
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