Kosykh V A, Surguchov A P, Podres E A, Novikov D K, Sudarickov A B, Repin V S, Smirnov V N
USSR Cardiology Research Center, Academy of Medical Sciences, Moscow.
FEBS Lett. 1988 May 9;232(1):103-6. doi: 10.1016/0014-5793(88)80395-8.
Incubation of cultured rabbit hepatocytes with beta very low density lipoproteins (beta-VLDL) induces a dose-dependent increase in cell cholesterol (CH) content and VLDL apoprotein (apo) B and E secretion without change in apo-B mRNA level. These data suggest that beta-VLDL may exert a stimulatory effect on hepatic apo-B production at the co-translational and/or posttranslational level.
用β极低密度脂蛋白（β-VLDL）孵育培养的兔肝细胞，可导致细胞胆固醇（CH）含量呈剂量依赖性增加，VLDL载脂蛋白（apo）B和E分泌增加，而apo-B mRNA水平无变化。这些数据表明，β-VLDL可能在共翻译和/或翻译后水平对肝脏apo-B的产生发挥刺激作用。
