VLDL apoprotein secretion and apo-B mRNA level in primary culture of cholesterol-loaded rabbit hepatocytes.

作者信息

Kosykh V A, Surguchov A P, Podres E A, Novikov D K, Sudarickov A B, Repin V S, Smirnov V N

机构信息

USSR Cardiology Research Center, Academy of Medical Sciences, Moscow.

出版信息

FEBS Lett. 1988 May 9;232(1):103-6. doi: 10.1016/0014-5793(88)80395-8.

Incubation of cultured rabbit hepatocytes with beta very low density lipoproteins (beta-VLDL) induces a dose-dependent increase in cell cholesterol (CH) content and VLDL apoprotein (apo) B and E secretion without change in apo-B mRNA level. These data suggest that beta-VLDL may exert a stimulatory effect on hepatic apo-B production at the co-translational and/or posttranslational level.