Department of Neurology, Zhongshan Hospital, Fudan University, 200032, Shanghai, China.
Department of Neurology, Zhongshan Hospital, Fudan University, 200032, Shanghai, China.
Brain Res Bull. 2021 Jun;171:67-74. doi: 10.1016/j.brainresbull.2021.02.025. Epub 2021 Mar 1.
Given the sheer increased number of victims per year and the availability of only one effective treatment, acute ischemic stroke (AIS) remains to be one of the most under-treated serious diseases. Diabetes not only increases the incidence of ischemic stroke, but amplifies the ischemic damage, upon which if patients with diabetes suffer from stroke, he/she will confront increased risks of long-term functional deficits. The grim reality makes it a pressing need to intensify efforts at the basic science level to understand how diabetes impairs stroke recovery. This review retrospects the clinical and experimental studies in order to elucidate the detrimental effect of diabetes on cerebrovascular circulation including the major arteries/arterioles, collateral circulation, and neovascularization to shed light on further exploration of novel strategies for cerebral circulation protection before and after AIS in patients with diabetes.
鉴于每年的受害者数量之多，以及仅有一种有效治疗方法，急性缺血性脑卒中（AIS）仍然是治疗不足的严重疾病之一。糖尿病不仅会增加缺血性中风的发病率，而且会加剧缺血性损伤，如果糖尿病患者患有中风，他们将面临长期功能缺陷的风险增加。严峻的现实使得我们迫切需要在基础科学层面加大努力，以了解糖尿病如何损害中风的恢复。本综述回顾了临床和实验研究，以阐明糖尿病对包括主要动脉/小动脉、侧支循环和新生血管形成在内的脑血管循环的有害影响，为进一步探索糖尿病患者 AIS 前后的新型脑循环保护策略提供了思路。
