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NTRK fusion in soft tissue sarcomas harboring MDM2/CDK4 amplification: three case reports.

作者信息

Brahmi M, Dufresne A, Verret B, Tirode F, Blay J Y

机构信息

Department of Medical Oncology, Centre Léon Bérard, Lyon, France; Cancer Research Center of Lyon, Centre Léon Bérard, Univ Lyon, Claude Bernard University Lyon 1, Lyon, France.

Department of Medical Oncology, Centre Léon Bérard, Lyon, France.

出版信息

Ann Oncol. 2021 Jun;32(6):813-814. doi: 10.1016/j.annonc.2021.02.019. Epub 2021 Mar 1.

DOI:10.1016/j.annonc.2021.02.019
PMID:33662498
Abstract
摘要

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Current management of neurotrophic receptor tyrosine kinase fusion-positive sarcoma: an updated review.神经营养性受体酪氨酸激酶融合阳性肉瘤的当前管理：最新综述
Jpn J Clin Oncol. 2025 Apr 6;55(4):313-326. doi: 10.1093/jjco/hyaf015.
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NTRK amplification occurs frequently in pan-TRK immunopositive dedifferentiated liposarcomas.NTRK基因扩增在泛TRK免疫阳性的去分化脂肪肉瘤中频繁发生。
Pathol Oncol Res. 2025 Jan 7;30:1611993. doi: 10.3389/pore.2024.1611993. eCollection 2024.
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Natural history and treatment efficacy in an ambispective case series of NTRK-rearranged mesenchymal tumors.
一项前瞻性病例系列研究中 NTRK 重排间叶肿瘤的自然病史和治疗效果。
ESMO Open. 2023 Apr;8(2):101202. doi: 10.1016/j.esmoop.2023.101202. Epub 2023 Apr 11.
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Marked Response to Larotrectinib in Pelvic Spindle Cell Sarcoma With Concurrent TPM3-NTRK1 Fusion and CDK4/MDM2 Amplification: A Case Report.盆腔梭形细胞肉瘤伴TPM3-NTRK1融合和CDK4/MDM2扩增对拉罗替尼有显著反应：一例报告
JCO Precis Oncol. 2023 Jan;7:e2200528. doi: 10.1200/PO.22.00528.
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Beyond targeting amplified MDM2 and CDK4 in well differentiated and dedifferentiated liposarcomas: From promise and clinical applications towards identification of progression drivers.除了在高分化和去分化脂肪肉瘤中靶向扩增的MDM2和CDK4：从前景与临床应用到鉴定进展驱动因素。
Front Oncol. 2022 Sep 2;12:965261. doi: 10.3389/fonc.2022.965261. eCollection 2022.