Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts.
VA RR&D Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Department of VA Medical Center, Providence, Rhode Island.
Semin Neurol. 2021 Apr;41(2):157-166. doi: 10.1055/s-0041-1725140. Epub 2021 Mar 4.
Neural repair is the underlying therapeutic strategy for many treatments currently under investigation to improve recovery after stroke. Repair-based therapies are distinct from acute stroke strategies: instead of salvaging threatened brain tissue, the goal is to improve behavioral outcomes on the basis of experience-dependent brain plasticity. Furthermore, timing, concomitant behavioral experiences, modality specific outcome measures, and careful patient selection are fundamental concepts for stroke recovery trials that can be deduced from principles of neural repair. Here we discuss core principles of neural repair and their implications for stroke recovery trials, highlighting related issues from key studies in humans. Research suggests a future in which neural repair therapies are personalized based on measures of brain structure and function, genetics, and lifestyle factors.
神经修复是目前许多治疗方法的基础治疗策略，旨在改善中风后的恢复。基于修复的治疗方法与急性中风策略不同：其目的不是挽救受到威胁的脑组织，而是基于经验依赖性脑可塑性，改善行为结果。此外，时机、伴随的行为经验、特定模式的结果测量和仔细的患者选择是中风恢复试验的基本概念，这些概念可以从神经修复的原则中推断出来。在这里，我们讨论神经修复的核心原则及其对中风恢复试验的影响，重点介绍人类关键研究中的相关问题。研究表明，未来神经修复疗法将基于大脑结构和功能、遗传学和生活方式因素的测量进行个性化。
