Department of Obstetrics and Gynecology, the Second Affiliated Hospital of University of South China, Hunan.
Institute of Basic Medicine, Hebei Medical University, Shijiazhuang.
Medicine (Baltimore). 2021 Feb 26;100(8):e23777. doi: 10.1097/MD.0000000000023777.
The subtypes of serous ovarian tumors (SOTs), including benign serous cystadenoma, serous borderline tumor (SBT), low-grade serous ovarian carcinoma (LGSC), and high-grade serous ovarian carcinoma (HGSC), remain poorly understood. Herein, we aimed to characterize the cell adhesion molecule 1 (CADM1)/signal transducer and activator of transcription 3 (STAT3)/human epidermal growth factor receptor 2 (HER2) axis and identify its clinical significance in patients with serous cystadenoma, SBT, LGSC, and HGSC.The immunohistochemical expression of CADM1, HER2, and STAT3 was assessed in 180 SOT specimens, and its association with clinical data was determined.High levels of CADM1 expression were detected in 100% of serous cystadenomas and 83.33% of SBTs, while a loss of CADM1 expression was observed in 44% of LGSCs and 72.5% of HGSCs. Relative to the levels in benign cystadenomas and SBTs, higher levels of HER2 and STAT3 expression were observed in LGSCs and aggressive HGSCs. Furthermore, the expression profile of the CADM1/HER2/STAT3 axis was significantly associated with histologic type, International Federation of Gynecology and Obstetrics stage, and lymph node metastasis in patients with SOT.Our study identified the changes in the CADM1/HER2/STAT3 axis that were closely associated with the clinical behavior of SOTs. These molecular data may provide new insights into SOT carcinogenesis and aid in the diagnosis and treatment of patients with SOT.
浆液性卵巢肿瘤（SOT）的亚型，包括良性浆液性囊腺瘤、浆液性交界性肿瘤（SBT）、低级别浆液性卵巢癌（LGSC）和高级别浆液性卵巢癌（HGSC），仍然知之甚少。在此，我们旨在描述细胞黏附分子 1（CADM1）/信号转导子和转录激活子 3（STAT3）/人表皮生长因子受体 2（HER2）轴，并确定其在浆液性囊腺瘤、SBT、LGSC 和 HGSC 患者中的临床意义。评估了 180 例 SOT 标本中 CADM1、HER2 和 STAT3 的免疫组织化学表达，并确定了其与临床数据的相关性。在 100%的浆液性囊腺瘤和 83.33%的 SBT 中检测到 CADM1 表达水平升高，而在 44%的 LGSC 和 72.5%的 HGSC 中观察到 CADM1 表达缺失。与良性囊腺瘤和 SBT 相比，LGSC 和侵袭性 HGSC 中 HER2 和 STAT3 的表达水平更高。此外，CADM1/HER2/STAT3 轴的表达谱与 SOT 患者的组织学类型、国际妇产科联合会分期和淋巴结转移显著相关。我们的研究确定了与 SOT 临床行为密切相关的 CADM1/HER2/STAT3 轴的变化。这些分子数据可能为 SOT 发生提供新的见解，并有助于 SOT 患者的诊断和治疗。
