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[三维光热功能化支架在颌面肿瘤术后骨修复中的应用进展]

[Advances in the application of three-dimensional photothermal functionalized scaffold for bone repairation after maxillofacial tumor surgery].

作者信息

Li F J, Li R X, Zou H R, Wang S, Liu H

机构信息

Department of Oral Maxillofacial Surgery, Tianjin Stomatological Hospital & Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin 300041, China.

Tianjin Stomatological Hospital & Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin 300041, China.

出版信息

Zhonghua Kou Qiang Yi Xue Za Zhi. 2021 Mar 9;56(3):283-287. doi: 10.3760/cma.j.cn112144-20200608-00322.

Abstract

The traditional treatment of maxillofacial tumors includes surgery and chemoradiotherapy. Surgery carries a high risk,and large bone defects are difficult to repair themselves. Besides, chemoradiotherapy can bring serious side effects. Therefore, how to repair the bone defects after maxillofacial tumor surgery and prevent tumor recurrence has become a major clinical challenge. In recent years, photothermal therapy has attracted much attention because of its low invasion, high efficiency, and no side effects. More and more photothermal materials have emerged and been applied in photothermal therapy. In order to treat tumor-related bone defects, many studies use three-dimensional printing technology to prepare photothermal functionalized scaffold to repair bone defects and prevent the recurrence of tumors. Based on photothermal therapy, the review states the photothermal materials, bone repair materials and photothermal functionalized scaffolds in the treatment of maxillofacial tumors at home and abroad, and provides a new way to solve the clinical challenge of bone defect and tumor recurrence after maxillofacial tumor surgery.

摘要

颌面部肿瘤的传统治疗方法包括手术以及放化疗。手术风险高,大的骨缺损难以自行修复。此外,放化疗会带来严重的副作用。因此,如何修复颌面部肿瘤手术后的骨缺损并预防肿瘤复发已成为一项重大的临床挑战。近年来,光热疗法因其微创、高效且无副作用而备受关注。越来越多的光热材料涌现并应用于光热疗法。为了治疗与肿瘤相关的骨缺损,许多研究采用三维打印技术制备光热功能化支架来修复骨缺损并预防肿瘤复发。基于光热疗法,本综述阐述了国内外用于治疗颌面部肿瘤的光热材料、骨修复材料以及光热功能化支架,为解决颌面部肿瘤手术后骨缺损和肿瘤复发的临床挑战提供了新途径。

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