Saxena Sandeep, Akduman Levent, Meyer Carsten H
Retina Service, Department of Ophthalmology, King George's Medical University, Luclnow, India.
Retina and Uveitis Service, Department of Ophthalmology, The Eye Institute, St. Louis University School of Medicine, St. Louis, MO, USA.
Int J Retina Vitreous. 2021 Mar 4;7(1):16. doi: 10.1186/s40942-021-00284-x.
Advances in spectral-domain optical coherence tomography (SD-OCT) technology have enhanced the understanding of external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema. An increase in VEGF has been demonstrated to be associated with sequential ELM and EZ disruption on SD-OCT. An intact ELM is a prerequisite for an intact EZ in DME. Anti-VEGF therapy leads to restoration of barrier effect of ELM. The ELM restores first followed by EZ restoration.
光谱域光学相干断层扫描（SD-OCT）技术的进展加深了我们对糖尿病性黄斑水肿中外界限制膜（ELM）和椭圆体带（EZ）的理解。研究表明，血管内皮生长因子（VEGF）增加与SD-OCT上ELM和EZ的相继破坏有关。在糖尿病性黄斑水肿中，完整的ELM是完整EZ的先决条件。抗VEGF治疗可导致ELM屏障作用的恢复。ELM先恢复，随后EZ恢复。
