Pu Dong Qing, Liu Zheng, Zhou Chao, Liang Jia Wei, Hao Qing Zhi
Traditional Chinese Medicine College,Shandong University of Chinese Medicine,Jinan 250014,China.
Department of Vascular Surgery,the Affiliated Hospital of Shandong University of Chinese Medicine,Jinan 250011,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2021 Feb 28;43(1):92-100. doi: 10.3881/j.issn.1000-503X.13266.
Objective To analyze the research status,hotspots,and frontiers of atherosclerosis genomics from 2010 to 2019.Methods CiteSpace software was used to conduct data statistics and visual analysis on countries,institutions,authors,journals,co-cited papers,and keywords of the related papers published in the Web of Science from 2010 to 2019.Results A total of 1021 papers in English were included,and the annual number of publications generally showed an upward trend.The knowledge base in the research of atherosclerosis mostly focused on the genetic risk sites and biomarkers for coronary artery diseases such as coronary heart disease,myocardial infarction,and dyslipidemia.The related journals mainly involved the fields of molecular biology,biology,genetics,immunology,medicine,pharmacy,and clinical medicine.The latest research in atherosclerosis concentrated on genome-wide association study,DNA methylation,microRNA,messenger RNA and so on.The research frontiers involved long noncoding RNA,DNA methylation,and immune metabolism.Conclusion The studies in atherosclerotic genomics have gradually increased.
目的 分析2010年至2019年动脉粥样硬化基因组学的研究现状、热点及前沿。方法 运用CiteSpace软件对2010年至2019年发表在Web of Science上的相关论文的国家、机构、作者、期刊、共被引论文及关键词进行数据统计和可视化分析。结果 共纳入1021篇英文论文，年发文量总体呈上升趋势。动脉粥样硬化研究的知识基础主要集中在冠心病、心肌梗死、血脂异常等冠状动脉疾病的遗传风险位点和生物标志物上。相关期刊主要涉及分子生物学、生物学、遗传学、免疫学、医学、药学及临床医学等领域。动脉粥样硬化的最新研究集中在全基因组关联研究、DNA甲基化、微小RNA、信使核糖核酸等方面。研究前沿涉及长链非编码RNA、DNA甲基化及免疫代谢。结论 动脉粥样硬化基因组学的研究逐渐增多。
