Xu Shengchao, Tang Lu, Dai Gan, Luo Chengke, Liu Zhixiong
Department of Neurosurgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Department of Thoracic Surgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Mol Ther Nucleic Acids. 2021 Feb 4;23:1229-1242. doi: 10.1016/j.omtn.2021.01.033. eCollection 2021 Mar 5.
Tumor microenvironment and alternative polyadenylation (APA) have drawn more attention in cancer research. However, their roles in grade II and III gliomas, termed as lower-grade glioma (LGG) in this study, remain to be fully elucidated. Here, we conducted this study and found that stromal and immune scores were elevated in higher grade and isocitrate dehydrogenase (IDH) wild-type glioma. Besides, higher stromal and immune scores indicated a poor prognosis in patients with LGG. APA events in immune-related genes were associated with overall survival, RNA expression, IDH mutation, and disease-free survival. Patients in the high-risk group had poor prognoses, and the risk score could be used to predict the survival rate. The risk score was positively correlated with the expression of immune checkpoints, inflammatory cytokines, and infiltrated immune cells. Moreover, risk stratification could predict the efficacy of radiotherapy and provide a reference for the treatment of grade III glioma. Our study revealed that immune-related genes with APA events in the microenvironment could predict risk stratification and clinical prognosis in patients with LGG.
肿瘤微环境与可变聚腺苷酸化（APA）在癌症研究中受到了更多关注。然而，它们在II级和III级胶质瘤（本研究中称为低级别胶质瘤，即LGG）中的作用仍有待充分阐明。在此，我们开展了本研究，发现高级别和异柠檬酸脱氢酶（IDH）野生型胶质瘤的基质和免疫评分升高。此外，较高的基质和免疫评分表明LGG患者预后不良。免疫相关基因中的APA事件与总生存期、RNA表达、IDH突变及无病生存期相关。高危组患者预后较差，风险评分可用于预测生存率。风险评分与免疫检查点、炎性细胞因子及浸润免疫细胞的表达呈正相关。此外，风险分层可预测放疗疗效，并为III级胶质瘤的治疗提供参考。我们的研究表明，微环境中发生APA事件的免疫相关基因可预测LGG患者的风险分层和临床预后。
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