Tran Diem Ngoc Hong, Hwang I-Hsuan, Chen Fun-Jou, Tseng Yuan-Pu, Chang Ching-Mao, Tsai Shih-Jen, Yang Jen-Lin, Wu Ta-Peng, Hsu Chung-Hua, Chen Fang-Pey, Kung Yen-Ying
Institute of Traditional Medicine, National Yang-Ming University, School of Medicine, Taipei, Taiwan.
Quality Management Center, Cheng Hsin General Hospital, Taiwan.
Integr Med Res. 2021 Sep;10(3):100707. doi: 10.1016/j.imr.2020.100707. Epub 2020 Dec 4.
Depressive disorders (DD) affect not only mood and behavior but also various physical functions. Traditional Chinese medicine (TCM) has been shown to have some benefits in treating DD. However, one formula or one single herb might be not show high efficacy when used to treat depression. Thus, this study aimed to examine the core prescription pattern of Chinese herbal medicine (CHM) among patients with DD in Taiwan as a reference for related research and clinical applications.
All patients, who had been diagnosed with major depressive disorder or minor depression or dysthymia without any other baseline diseases and had at least one CHM outpatient clinical visit from 2002 to 2011, were extracted from three randomly sampled cohorts, namely the 2000, 2005 and 2010 cohorts of the National Health Insurance Research Database (NHIRD) of Taiwan. The collected data was analyzed to explore the patterns of herbal products.
There were 197,146 patients with a diagnosis of DD and of these 1806 subjects had only a diagnosis of DD and utilized CHM. The most common formula was (12.19%), while (3.99%) was the most commonly prescribed single herb. The core pattern of prescriptions consisted of a combination of and .
This study describes the CHM core prescription pattern used to treat patients in Taiwan with DD and it is a potential candidate for study in future pharmacological or clinical trials targeting DD.
抑郁症不仅会影响情绪和行为，还会影响各种身体功能。中医已被证明在治疗抑郁症方面有一定益处。然而，单一的方剂或草药在治疗抑郁症时可能效果不佳。因此，本研究旨在探讨台湾抑郁症患者使用中药的核心处方模式，为相关研究和临床应用提供参考。
从台湾国民健康保险研究数据库（NHIRD）的2000、2005和2010三个随机抽样队列中提取所有在2002年至2011年期间被诊断为重度抑郁症、轻度抑郁症或心境恶劣且无任何其他基础疾病且至少有一次中医门诊就诊记录的患者。对收集的数据进行分析，以探索草药产品的使用模式。
共有197146名被诊断为抑郁症的患者，其中1806名仅被诊断为抑郁症且使用了中药。最常用的方剂是 （12.19%），而最常用的单味草药是 （3.99%）。核心处方模式为 与 的组合。
本研究描述了台湾用于治疗抑郁症患者的中药核心处方模式，它是未来针对抑郁症的药理或临床试验研究的潜在候选对象。
