在初级保健机构中开展的阿尔茨海默病风险评估项目的初步研究。
Pilot study of an Alzheimer's disease risk assessment program in a primary care setting.
作者信息
Korthauer Laura E, Denby Charles, Molina David, Wanjiku Janet, Daiello Lori A, Drake Jonathan D, Grill Josh D, Ott Brian R
机构信息
Department of Psychiatry and Human Behavior Alpert Medical School of Brown University Rhode Island Hospital Providence Rhode Island USA.
Department of Neurology Alpert Medical School of Brown University Rhode Island Hospital Providence Rhode Island USA.
出版信息
Alzheimers Dement (Amst). 2021 Feb 20;13(1):e12157. doi: 10.1002/dad2.12157. eCollection 2021.
INTRODUCTION
The goal of this study was to pilot a referral-based cognitive screening and genetic testing program for Alzheimer's disease (AD) risk assessment in a primary care setting.
METHODS
Primary care providers (PCPs; = 6) referred patients ( = 94; = 63 years) to the Rhode Island Alzheimer's Disease Prevention Registry for apolipoprotein E (APOE) genotyping and cognitive screening. PCPs disclosed test results to patients and counseled them about risk factor modification.
RESULTS
Compared to the Registry as a whole, participants were younger, more likely to be non-White, and had lower cognitive screening scores. Mild cognitive impairment participants correctly reported a higher perceived risk of developing AD. Patients who recalled being counseled about modifiable risk factors were more likely to report positive health behavior changes.
DISCUSSION
A referral-based program for cognitive and genetic AD risk assessment in a primary care setting is feasible, acceptable to patients, and yielded a more demographically diverse sample than an AD prevention registry.
引言
本研究的目的是在初级保健环境中试点一项基于转诊的认知筛查和基因检测项目，用于阿尔茨海默病（AD）风险评估。
方法
初级保健提供者（PCP；共6名）将患者（共94名；平均年龄63岁）转诊至罗德岛阿尔茨海默病预防登记处进行载脂蛋白E（APOE）基因分型和认知筛查。初级保健提供者向患者披露检测结果，并就风险因素调整为他们提供咨询。
结果
与整个登记处相比，参与者更年轻，更有可能是非白人，且认知筛查得分更低。轻度认知障碍参与者正确报告了更高的AD发病感知风险。回忆起曾接受可改变风险因素咨询的患者更有可能报告有积极的健康行为改变。
讨论
在初级保健环境中开展基于转诊的AD认知和基因风险评估项目是可行的，患者可以接受，并且与AD预防登记处相比，该项目产生的样本在人口统计学上更加多样化。
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