Lisbona González María Jesús, Reyes Botella Candela, Muñoz Soto Esther, Olmedo Gaya Maria Victoria, Moreno Fernández Jorge, Díaz Castro Javier
Departamento de Estomatología. Facultad de Odontología. Universidad de Granada.
Instituto de Nutrición y Tecnología de los Alimentos "José Mataix". Universidad de Granada.
Nutr Hosp. 2021 Jun 10;38(3):585-591. doi: 10.20960/nh.03438.
Introduction: propolis and its components influence lipid metabolism; however, its effect on body composition and mineral metabolism remains unknown. Objectives: to determine the effect of natural propolis supplementation on body composition, mineral metabolism, and the endocrine function of adipose tissue. Material and methods: twenty albino male Wistar rats (8 weeks old) were divided into two groups of 10 animals each. The rats were fed two different types of diet for 90 days: a standard diet for the control group (group C) and the same standard diet + 2 % propolis (group P). Thyroid hormones, ghrelin, leptin, adiponectin and insulin, non-esterified fatty acids (NEFA) in plasma, body composition (lean mass, fat mass and body water), and mineral deposition in target organs (spleen, brain, heart, lungs, testicles, kidneys and femur) were assessed. Results: thyroid stimulating hormone (TSH), triiodothyronine (T3) and thyroxine (T4) did not show any differences after supplementation with propolis, while ghrelin and adiponectin decreased (p < 0.01 and p < 0.05, respectively) and insulin (p < 0.01), leptin (p < 0.05) and NEFA (p < 0.05) increased when 2 % propolis was supplied, while weight and body fat were reduced (p < 0.05) and lean mass increased. Lastly, the propolis supplement improves calcium deposition in the spleen, lungs, testes, and femur (p < 0.05). Conclusion: propolis supplementation of the diet (2 %) causes a decrease in the secretion of ghrelin and adiponectin, increasing the release of non-esterified fatty acids and the rate of insulin secretion. In addition, propolis supplementation induces an improvement in calcium deposition in target organs without affecting the rest of minerals, which improves body composition by inducing a reduction in weight and visceral adipose tissue, and improvement in lean mass.
蜂胶及其成分会影响脂质代谢；然而，其对身体成分和矿物质代谢的影响尚不清楚。目的：确定补充天然蜂胶对身体成分、矿物质代谢及脂肪组织内分泌功能的影响。材料与方法：将20只8周龄的白化雄性Wistar大鼠分为两组，每组10只。大鼠分别喂食两种不同的饲料，持续90天：对照组（C组）喂食标准饲料，蜂胶组（P组）喂食相同的标准饲料+2%蜂胶。评估甲状腺激素、胃饥饿素、瘦素、脂联素和胰岛素、血浆中非酯化脂肪酸（NEFA）、身体成分（瘦体重、脂肪量和身体水分）以及靶器官（脾脏、大脑、心脏、肺、睾丸、肾脏和股骨）中的矿物质沉积。结果：补充蜂胶后，促甲状腺激素（TSH）、三碘甲状腺原氨酸（T3）和甲状腺素（T4）无差异，而补充2%蜂胶时，胃饥饿素和脂联素降低（分别为p<0.01和p<0.05），胰岛素（p<0.01）、瘦素（p<0.05）和NEFA（p<0.05）升高，同时体重和体脂减少（p<0.05），瘦体重增加。最后，蜂胶补充剂可改善脾脏、肺、睾丸和股骨中的钙沉积（p<0.05）。结论：饮食中补充2%蜂胶会导致胃饥饿素和脂联素分泌减少，增加非酯化脂肪酸的释放和胰岛素分泌率。此外，补充蜂胶可改善靶器官中的钙沉积，而不影响其他矿物质，通过减轻体重和内脏脂肪组织以及增加瘦体重来改善身体成分。
