Department of Dermatology, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Korea.
Eczema Research Association of Catholic Medical Center, Seoul, Korea.
J Dermatol. 2021 May;48(5):625-632. doi: 10.1111/1346-8138.15817. Epub 2021 Mar 5.
The involvement of genital lesions in patients with atopic dermatitis (AD) is poorly understood. Moreover, clinical characteristics, potentially related factors, and impact on the quality of life (QOL) of genital eczema in patients with AD are also largely unknown. This study aims to evaluate the prevalence and burden of genital eczema in patients with AD. A prospective cross-sectional study recruited a total of 220 patients diagnosed with AD. The participants were asked to complete the self-administrated questionnaire asking sociodemographic characteristics, details about their AD, and individual experiences of their genital eczema. Among 220 responders, 99 patients (45.00%) reported that they had experienced genital eczema at some time during the course of AD. Longer disease duration (odds ratio [OR], 2.29; 95% confidence interval [CI], 1.13-4.62; p = 0.02), marital status (OR, 0.43; 95% CI, 0.21-0.89; p = 0.003), involvement of the trunk (OR, 3.44; 95% CI, 1.81-6.52; p = 0.001), and involvement of the nipple (OR, 6.20; 95% CI, 1.39-27.63; p = 0.017) were the significant associated factors for the presence of genital eczema among patients with AD. Of note, the severe impairment of genital eczema-specific QOL was observed in 28.29% of AD patients with genital eczema. Especially, female sex (OR, 2.22; 95% CI, 0.84-5.82; p = 0.04) was more associated with severe impairment of genital eczema-specific QOL. Many patients with AD suffer from the genital presentation of the disease. Moreover, genital involvement of the disease has a significant impact on the QOL of patients with AD. We suggest that more attention should be paid to the genital presentation of the disease to increase QOL and provide further delicate treatment of patients with AD.
特应性皮炎（AD）患者的生殖器病变涉及甚少。此外，AD 患者生殖器湿疹的临床特征、潜在相关因素及其对生活质量（QOL）的影响也知之甚少。本研究旨在评估 AD 患者生殖器湿疹的患病率和负担。一项前瞻性横断面研究共招募了 220 名诊断为 AD 的患者。参与者被要求完成自我管理问卷，询问社会人口统计学特征、AD 详细信息以及他们生殖器湿疹的个人经历。在 220 名应答者中，99 名（45.00%）患者报告在 AD 病程中曾有过生殖器湿疹。疾病持续时间较长（优势比[OR]，2.29；95%置信区间[CI]，1.13-4.62；p=0.02）、婚姻状况（OR，0.43；95%CI，0.21-0.89；p=0.003）、躯干受累（OR，3.44；95%CI，1.81-6.52；p=0.001）和乳头受累（OR，6.20；95%CI，1.39-27.63；p=0.017）是 AD 患者生殖器湿疹存在的显著相关因素。值得注意的是，28.29%的 AD 患者有生殖器湿疹，其生殖器湿疹的特定 QOL 严重受损。特别是女性（OR，2.22；95%CI，0.84-5.82；p=0.04）与生殖器湿疹特定 QOL 的严重受损更相关。许多 AD 患者患有生殖器疾病。此外，疾病的生殖器受累对 AD 患者的 QOL 有重大影响。我们建议应更加关注疾病的生殖器表现，以提高 QOL，并为 AD 患者提供更精细的治疗。
