阻塞性睡眠呼吸暂停患者中簇集蛋白和补体因子 H 的循环水平。

Circulating levels of clusterin and complement factor H in patients with obstructive sleep apnea.

机构信息

Department of Pulmonology, Semmelweis University, Budapest, Hungary.

Department of Radiology, Oncologic Imaging Diagnostic Center, National Institute of Oncology, Budapest, Hungary.

出版信息

Biomark Med. 2021 Apr;15(5):323-330. doi: 10.2217/bmm-2020-0533. Epub 2021 Mar 5.

DOI:10.2217/bmm-2020-0533

PMID:33666516

Abstract

Obstructive sleep apnea (OSA) activates the complement system; however, the levels of membrane attack complex (MAC) are unaltered suggesting regulatory mechanisms. Our aim was to investigate complement factor H (CFH) and clusterin, two important complement regulators in OSA. We analyzed clusterin and CFH levels in plasma of 86 patients with OSA and 33 control subjects. There was no difference in CFH levels between patients (1099.4/784.6-1570.5/μg/ml) and controls (1051.4/652.0-1615.1/μg/ml, p = 0.72). Clusterin levels were higher in patients with OSA (309.7/217.2-763.2/μg/ml vs 276.1/131.0-424.3/μg/ml, p = 0.048) with a trend for a positive correlation with disease severity (p = 0.073). Increase in clusterin levels may be protective in OSA by blocking the MAC formation.

摘要

阻塞性睡眠呼吸暂停（OSA）会激活补体系统；然而，膜攻击复合物（MAC）的水平没有改变，这表明存在调节机制。我们的目的是研究补体因子 H（CFH）和簇蛋白，这两种在 OSA 中重要的补体调节因子。我们分析了 86 例 OSA 患者和 33 例对照者血浆中的簇蛋白和 CFH 水平。患者（1099.4/784.6-1570.5/μg/ml）和对照组（1051.4/652.0-1615.1/μg/ml，p=0.72）之间 CFH 水平没有差异。OSA 患者的簇蛋白水平较高（309.7/217.2-763.2/μg/ml 与 276.1/131.0-424.3/μg/ml，p=0.048），且与疾病严重程度呈正相关趋势（p=0.073）。簇蛋白水平的升高可能通过阻止 MAC 形成对 OSA 具有保护作用。