Core Facility Center, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
Dokl Biochem Biophys. 2021 Mar;497(1):71-74. doi: 10.1134/S1607672921020137. Epub 2021 Mar 5.
Under conditions of lymphopenia, T lymphocytes proliferate and acquire a surface activation phenotype, which in many respects is similar to the phenotype of true memory T cells. We investigated the phenotypic features of the CD8+ T-cell population formed from donor lymphocytes after adoptive transfer of syngeneic splenocytes to sublethally irradiated mice. This population expresses markers CD44, CD122, CD5, CD49d and the chemokine receptor CXCR3. Thus, for the first time, the phenomenon of the formation of a population of T cells with signs of suppressive CD8+ T lymphocytes and true memory cells was demonstrated.
在淋巴细胞减少症的情况下，T 淋巴细胞增殖并获得表面激活表型，在许多方面与真正的记忆 T 细胞表型相似。我们研究了从同种脾细胞过继转移到亚致死照射小鼠后形成的供体淋巴细胞的 CD8+ T 细胞群体的表型特征。该群体表达标志物 CD44、CD122、CD5、CD49d 和趋化因子受体 CXCR3。因此，我们首次证明了形成具有抑制性 CD8+ T 淋巴细胞和真正记忆细胞特征的 T 细胞群体的现象。
