Griffiths F, Parekh S
Eastman Dental Institute, University College London, 123 Grays Inn Road, Holborn, London, WC1X 8LT, UK.
Eur Arch Paediatr Dent. 2021 Aug;22(4):759-763. doi: 10.1007/s40368-021-00609-2. Epub 2021 Mar 5.
The aim of this study was to determine whether carbamide peroxide is effective in bleaching vital permanent teeth in children.
A literature search was conducted using all keywords relevant to the research subject. The outcome measures were identified as colour change, tooth sensitivity, oral irritation and patient satisfaction. The certainty of evidence for each outcome was assessed using the current GRADE guidelines.
Of 115 potentially relevant articles, 112 were excluded, as they did not exclusively involve children, intervention involved additional treatment such as microabrasion or restorative work, or case studies. Patient satisfaction was not assessed in the three articles so no analysis could be made with regards to this outcome. The GRADE assessment showed that all of the three articles demonstrated very low certainty of evidence for the other assessed outcomes. The overall findings from the studies suggest that a 10% carbamide peroxide overnight tray system is effective at bleaching vital permanent teeth in children and associated tooth sensitivity and oral irritation are found to be in a similar range compared to those reported in adult studies. However, due to the very low certainty of the evidence, it is not possible to draw these conclusions.
Better quality randomised controlled trials are needed to investigate the indication, short and long term effectiveness and side effects of carbamide teeth in vital permanent teeth in children.
本研究旨在确定过氧化脲对儿童恒牙进行漂白是否有效。
使用与研究主题相关的所有关键词进行文献检索。将结果指标确定为颜色变化、牙齿敏感、口腔刺激和患者满意度。使用当前的GRADE指南评估每个结果的证据确定性。
在115篇可能相关的文章中，排除了112篇，因为它们并非专门针对儿童，干预措施涉及微打磨或修复工作等额外治疗，或者是案例研究。在这三篇文章中未评估患者满意度，因此无法对该结果进行分析。GRADE评估显示，这三篇文章对于其他评估结果的证据确定性均非常低。研究的总体结果表明，10%过氧化脲夜间托盘系统对儿童恒牙进行漂白是有效的，并且发现相关的牙齿敏感和口腔刺激与成人研究中报告的范围相似。然而，由于证据确定性非常低，无法得出这些结论。
需要开展质量更高的随机对照试验，以研究过氧化脲对儿童恒牙漂白的适应症、短期和长期有效性以及副作用。
