Department of Biomedicine, Experimental Hematology, University Hospital Basel and University of Basel, Basel, Switzerland.
Institute of Integrative Biology, ETH Zürich, Zürich, Switzerland.
Cell Stem Cell. 2021 Mar 4;28(3):359-361. doi: 10.1016/j.stem.2021.02.018.
Myeloproliferative neoplasms (MPNs) are hematological malignancies caused by somatic mutations originating from a single hematopoietic stem cell (HSC). In this issue of Cell Stem Cell,Van Egeren et al. (2021) used whole-genome sequencing of hematopoietic colonies to reconstruct the clonal history and time of acquisition of the disease-initiating gene mutation.
骨髓增殖性肿瘤（MPNs）是由起源于单个造血干细胞（HSC）的体细胞突变引起的血液系统恶性肿瘤。在本期《Cell Stem Cell》杂志上，Van Egeren 等人（2021 年）利用造血集落的全基因组测序来重建疾病起始基因突变的克隆历史和获得时间。
