钟声为谁而鸣：死亡激酶 IRAK3 的结构。
For Whom the Bell Tolls: The Structure of the Dead Kinase, IRAK3.
机构信息
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.
出版信息
Structure. 2021 Mar 4;29(3):197-199. doi: 10.1016/j.str.2021.01.011.
In this issue of Structure, Lange et al. (2020) report the structure of the pseudokinase domain of IRAK3, a negative regulator of Myddosome inflammatory signaling. The IRAK3 pseudokinase domain forms a head-to-head dimer, suggesting a new mode of kinase/pseudokinase allostery by which IRAK3 could attenuate the activity of IRAK4 in cells.
在本期《结构》中，Lange 等人（2020 年）报告了 IRAK3 蛋白的伪激酶结构域的结构，IRAK3 是 Myddosome 炎症信号的负调控因子。IRAK3 伪激酶结构域形成头对头二聚体，提示了一种新的激酶/伪激酶变构模式，通过这种模式，IRAK3 可以在细胞中减弱 IRAK4 的活性。
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