打开更好的阿司匹林之门。

Opening the Door to Better Aspirin.

机构信息

Department of Drug Discovery Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.

Department of Drug Discovery Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan; AMED-FORCE, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan.

出版信息

Structure. 2021 Mar 4;29(3):200-202. doi: 10.1016/j.str.2021.02.003.

DOI:10.1016/j.str.2021.02.003

PMID:33667375

Abstract

In this issue of Structure, Nojima et al. (2021) report the structure of the PGE-EP4-G complex by cryo-electron microscopy. This work shows unique modes of ligand binding, transduction mechanism, and G protein coupling of EP4, and serves as a starting point for development of more selective drugs.

摘要

在本期《结构》杂志中，野岛等人（2021）通过冷冻电镜报告了 PGE-EP4-G 复合物的结构。这项工作展示了 EP4 的独特配体结合方式、转导机制和 G 蛋白偶联，为开发更具选择性的药物提供了起点。