单胺氧化酶抑制剂（MAOI）或三环类抗抑郁药反应者中与过早停药相关的因素。
Factors associated with premature medication discontinuation among responders to an MAOI or a tricyclic antidepressant.
作者信息
Agosti V, Stewart J W, Quitkin F M, Rabkin J G, McGrath P J, Markowitz J
机构信息
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York.
出版信息
J Clin Psychiatry. 1988 May;49(5):196-8.
PMID:3366755
Abstract
The charts of 80 outpatients who responded to antidepressants were reviewed to determine if there was a higher rate of premature medication discontinuation with phenelzine than with imipramine. The phenelzine responders had a significantly (p less than .01) higher rate of drug discontinuation, mainly because of side effects. Controlled studies of long-term use are needed to better explain the problem of attrition.
摘要
回顾了80名对抗抑郁药有反应的门诊患者的病历，以确定苯乙肼导致的过早停药率是否高于丙咪嗪。苯乙肼治疗有效的患者停药率显著更高（p<0.01），主要原因是副作用。需要进行长期使用的对照研究，以更好地解释脱落问题。
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