从 Neoshirakia japonica 中分离得到具有抑制小胶质细胞一氧化氮产生作用的类黄酮糖苷和苯丙素糖苷。
Flavonol glycosides and phenylpropanoid glycosides with inhibitory effects on microglial nitric oxide production from Neoshirakia japonica.
机构信息
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China; College of Food and Biochemical Engineering, Guangxi Science & Technology Normal University, Laibin 546199, People's Republic of China.
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China.
出版信息
Fitoterapia. 2021 Jun;151:104877. doi: 10.1016/j.fitote.2021.104877. Epub 2021 Mar 3.
Five new flavonol glycosides (1-5), one new phenylpropanoid glycoside (6), and nine known glycosides (7-15) were isolated from the stems and leaves of Neoshirakia japonica. The structures of the new compounds were determined by detailed analysis of spectroscopic data (HRESIMS, 1D and 2D NMR) and acid hydrolysis experiment. The antineuroinflammatory effects of all the isolates were evaluated by inhibiting NO production against LPS-induced BV-2 microglial cells. Compounds 1, 8, and 9 showed more potent inhibitory activities with IC values of 2.7, 5.5, and 4.1 μM, respectively, than that of the positive control minocycline (IC = 15.6 μM), while compounds 7 (IC = 17.0 μM) and 10 (IC = 24.3 μM) also displayed inhibitory activities to a certain degree.
从 Neoshirakia japonica 的茎和叶中分离得到了五个新的黄酮醇糖苷（1-5）、一个新的苯丙素糖苷（6）和九个已知的糖苷（7-15）。通过详细分析光谱数据（HRESIMS、1D 和 2D NMR）和酸水解实验确定了新化合物的结构。通过抑制 LPS 诱导的 BV-2 小胶质细胞中 NO 产生来评估所有分离物的抗神经炎症作用。化合物 1、8 和 9 具有更强的抑制活性，IC 值分别为 2.7、5.5 和 4.1 μM，优于阳性对照米诺环素（IC = 15.6 μM），而化合物 7（IC = 17.0 μM）和 10（IC = 24.3 μM）也具有一定的抑制活性。
Zotero 插件