Columbia University, Department of Pathology and Cell Biology, United States.
Columbia University, Department of Pathology and Cell Biology, United States.
Neurosci Lett. 2021 May 1;752:135796. doi: 10.1016/j.neulet.2021.135796. Epub 2021 Mar 2.
Cytoplasmic dynein is responsible for all forms of retrograde transport in neurons and other cells. Work over several years has led to the identification of a class of coiled-coil domain containing "adaptor" proteins that are responsible for expanding dynein's range of cargo interactions, as well as regulating dynein motor behavior. This brief review focuses first on the BicD family of adaptor proteins, which clearly serve to expand the number of dynein cargo interactions. RILP, another adaptor protein, also interacts with multiple proteins. Surprisingly, this is to mediate a series of steps within a common pathway, higher eukaryotic autophagy. These distinct features have important implications for understanding the full range of dynein adaptor functions.
细胞质动力蛋白负责神经元和其他细胞中所有形式的逆行运输。多年的工作已经确定了一类卷曲螺旋结构域包含的“衔接”蛋白，这些蛋白负责扩展动力蛋白的货物相互作用范围，并调节动力蛋白的运动行为。本综述首先集中讨论衔接蛋白 BicD 家族，它显然有助于增加动力蛋白的货物相互作用数量。另一种衔接蛋白 RILP 也与多种蛋白质相互作用。令人惊讶的是，这是在一个共同途径内介导一系列步骤，即高等真核生物自噬。这些不同的特征对于理解动力蛋白衔接子功能的全部范围具有重要意义。
