Istanbul Medeniyet University, Faculty of Medicine, Goztepe Training and Research Hospital, Department of Plastic and Reconstructive Surgery, Eğitim, Dr. Erkin Cd., 34722 Kadıköy/Istanbul, Turkey.
Istanbul Medeniyet University, Faculty of Medicine, Goztepe Training and Research Hospital, Department of Plastic and Reconstructive Surgery, Eğitim, Dr. Erkin Cd., 34722 Kadıköy/Istanbul, Turkey.
Hand Surg Rehabil. 2021 Jun;40(3):250-257. doi: 10.1016/j.hansur.2021.01.005. Epub 2021 Mar 2.
Adhesion after a tendon injury is one of the major problems following upper extremity surgery. In the present study, we evaluated a new material that is clinically usable as an adhesion barrier. Twenty-four male Wistar albino rats were used in the study. These rats (48 legs) were divided into three groups: sham, control, and experimental. No surgical intervention was performed in the sham group. After making a full-thickness cut through the right Achilles tendon, the tendon was repaired using the modified Kessler technique in the control group, while bovine collagen matrix was wrapped around the surgically repaired tendon using the modified Kessler technique in the experimental group. Two months after surgery, the operated and non-operated tendons were resected and analyzed through biomechanical, macroscopic, and histopathological examinations. The results of the biomechanical testing did not differ significantly between the control and experimental groups. Macroscopic examination of the adhesions revealed less adhesions in the experimental group but this difference was not statistically significant. Moreover, the results of the histopathological examination, which was performed based on five criteria, did not differ significantly between the two groups. Our study's results indicate that a bovine collagen matrix can be used to prevent tendon adhesion; however, larger studies are needed to verify these findings.
腱损伤后的粘连是上肢手术后的主要问题之一。在本研究中，我们评估了一种新的可在临床上用作粘连屏障的材料。本研究使用了 24 只雄性 Wistar 白化大鼠，将其分为三组：假手术组、对照组和实验组。假手术组不进行任何手术干预。在对照组中，通过改良 Kessler 技术修复右跟腱全层切口，在实验组中，通过改良 Kessler 技术将牛胶原基质包裹在手术修复的肌腱周围。术后 2 个月，切除手术和非手术的肌腱，并通过生物力学、宏观和组织病理学检查进行分析。生物力学测试结果在对照组和实验组之间无显著差异。宏观粘连检查显示实验组粘连较少，但差异无统计学意义。此外，根据五个标准进行的组织病理学检查结果在两组之间无显著差异。我们的研究结果表明，牛胶原基质可用于预防肌腱粘连；然而，需要更大规模的研究来验证这些发现。
